[1]夏仙仙,蔡丙杰,沙 珂,等.尖锐湿疣组织中Bad和增殖细胞核抗原蛋白表达的检测[J].郑州大学学报(医学版),2018,(01):114-117.[doi:10.13705/j.issn.1671-6825.2017.06.072]
 XIA Xianxian,CAI Bingjie,SHA Ke,et al.Detection of pro-apoptotic protein Bad and proliferating cell nuclear antigen in condyloma acuminatum[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(01):114-117.[doi:10.13705/j.issn.1671-6825.2017.06.072]
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尖锐湿疣组织中Bad和增殖细胞核抗原蛋白表达的检测()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年01期
页码:
114-117
栏目:
应用研究
出版日期:
2018-01-20

文章信息/Info

Title:
Detection of pro-apoptotic protein Bad and proliferating cell nuclear antigen in condyloma acuminatum
作者:
夏仙仙蔡丙杰沙 珂潘信心尹光文
郑州大学第一附属医院皮肤科 郑州 450052
Author(s):
XIA XianxianCAI BingjieSHA KePAN XinxinYIN Guangwen
Department of Dermatology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
尖锐湿疣 促凋亡蛋白Bad 增殖细胞核抗原
Keywords:
condyloma acuminatum Bad proliferating cell nuclear antigen
分类号:
R75
DOI:
10.13705/j.issn.1671-6825.2017.06.072
摘要:
目的:探讨尖锐湿疣(CA)组织中促凋亡蛋白Bad和增殖细胞核抗原(PCNA)的表达及其可能意义。方法:采用免疫组化SP法分别检测53例CA和28例正常包皮上皮组织中Bad和PCNA蛋白的表达情况。结果:53例CA组织中Bad和PCNA蛋白的阳性表达率分别为69.8%(37/53)和86.8%(46/53),而在正常包皮上皮组织中的阳性表达率均为28.6%(8/28)和39.3%(11/28),CA组织中Bad和PCNA阳性表达强度均在~,而包皮上皮组织中Bad和PCNA阳性表达强度均在+~; CA和正常包皮上皮组织中Bad、PCNA蛋白的表达强度差异有统计学意义(ZBad=3.805,ZPCNA=5.426,P<0.001)。CA组织中Bad和PCNA蛋白的表达呈正相关(rP=0.134,P=0.325)。结论:Bad和PCNA蛋白的过表达可能对CA的发生和发展有一定的促进作用。
Abstract:
Aim: To investigate the expression of pro-apoptotic protein Bad and proliferating cell nuclear antigen(PCNA)in condyloma acuminatum(CA)tissue and its relationship with the pathogenesis of CA.Methods: The expression of Bad and PCNA in 53 cases of CA and 28 cases of normal epithelium tissue were detected by immunohistochemical SP method.Results: The positive rates of Bad and PCNA in CA tissue were respectively 69.8%(37/53)and 86.8%(46/53)and were 28.6%(8/28)and 39.3%(11/28)in normal epithelial tissue. The expression intensity of Bad and PCNA in CA tissue was obviously higher(-)than that in normal epithelium tissue(+-).The difference in expression intensity of Bad and PCNA between the two groups was statistically significant(ZBad=3.805,ZPCNA=5.426; P<0.001). In addition, there was no significant correlation between the expression of Bad and PCNA in CA group(rP=0.134,P=0.325).Conclusion: The overexpression of Bad and PCNA may be associated with the occurrence and development of CA.

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金资助项目(81650026)
【作者简介】尹光文,通信作者,男,1967年9月生,博士,教授,主任医师,研究方向:皮肤性病学, E-mail:gwyin67@126.com
更新日期/Last Update: 2018-01-20