[1]邢 鑫,张自森,郭彦伟,等.血清骨桥蛋白、癌胚抗原及CK18的表达对胃癌的诊断价值[J].郑州大学学报(医学版),2018,(02):221-224.[doi:10.13705/j.issn.1671-6825.2017.07.083]
 XING Xin,ZHANG Zisen,GUO Yanwei,et al.Significance of serum osteopontin,CEA and CK18 for gastric cancer diagnosis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(02):221-224.[doi:10.13705/j.issn.1671-6825.2017.07.083]
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血清骨桥蛋白、癌胚抗原及CK18的表达对胃癌的诊断价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年02期
页码:
221-224
栏目:
应用研究
出版日期:
2018-03-20

文章信息/Info

Title:
Significance of serum osteopontin,CEA and CK18 for gastric cancer diagnosis
作者:
邢 鑫张自森郭彦伟王利娟张红巧郑晓珂张 剑王亚楠
郑州大学第五附属医院肿瘤内科 郑州 450052
Author(s):
XING XinZHANG ZisenGUO YanweiWANG LijuanZHANG HongqiaoZHENG XiaokeZHANG JianWANG Yanan
Department of Oncology,the Fifth Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
胃癌 骨桥蛋白 癌胚抗原 细胞角蛋白18
Keywords:
gastric cancer osteopontin carcinoembryonic antigen cytokeratin 18
分类号:
R735.2
DOI:
10.13705/j.issn.1671-6825.2017.07.083
摘要:
目的:测定胃癌患者血清中骨桥蛋白(OPN)、癌胚抗原(CEA)和细胞角蛋白18(CK18)的表达情况,探讨其在胃癌诊断中的意义。方法:选择80例胃癌患者作为胃癌组,80名健康体检者作为对照组,观察胃癌组和对照组血清OPN、CEA和CK18含量,血清OPN和CEA、CK18诊断胃癌的灵敏度、特异度及ROC曲线下面积,血清OPN、CEA和CK18含量和胃癌病理特征的关系。结果:胃癌组患者血清OPN、CEA和CK18含量均高于对照组(P<0.05)。血清OPN诊断胃癌的ROC曲线下面积大于血清CEA和CK18,两两联合指标诊断胃癌的ROC曲线下面积大于单独指标,三者联合诊断胃癌的ROC曲线下面积最大。随着联合指标的增多,诊断胃癌的灵敏度升高。结论:胃癌患者血清OPN、CEA和CK18水平升高,多指标联合检测诊断胃癌的灵敏度比较高。
Abstract:
Aim: To detect the value of the expressions of serum osteopontin(OPN), carcinoembryonic antigen(CEA)and cytokeratin18(CK18)in gastric cancer diagnosis.Methods: A total of 80 cases of gastric cancer patients were selected as gastric cancer group and 80 healthy individuals as control group. The contents of serum OPN,CEA and CK18 in the 2 groups were determined, the sensitivity, specificity and area under the ROC curve of serum OPN and CEA, CK18 contents in diagnosis of gastric cancer were caculated, and the relationship between serum OPN, CEA and CK18 contents and pathological features of gastric cancer was analyzed.Results: The contents of serum OPN, CEA and CK18 in gastric cancer group were higher than those in control group(P<0.05). The area under the ROC curve of serum OPN was larger than serum CEA and CK18 in diagnosis of gastric cancer, the two-two joint indexes in diagnosis of gastric cancer had the largert area under the ROC curve than individual indicator, and the three indicators joint had the largest area under the ROC curve. With the joint index increasing, the diagnosis sensitivity of gastric cancer increased.Conclusion: The contents of serum OPN, CEA and CK18 of patient with gastric cancer are elevated, and the sensitivity of multiple indicators in diagnosis of gastric cancer is relatively high.

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备注/Memo

备注/Memo:
【基金项目】郑州市科技攻关项目(15pkjgg169)
【作者简介】张自森,通信作者,男,1979年8月生,博士,副主任医师,研究方向:恶性肿瘤的综合治疗,E-mail:zzs15423@163.com
更新日期/Last Update: 2018-03-20