[1]许春杰),刘晓宇),尹素凤),等.基于剂量-反应关系的体力活动对血清肌酐水平的影响及其性别差异[J].郑州大学学报(医学版),2018,(02):225-229.[doi:10.13705/j.issn.1671-6825.2017.06.081]
 Relationship between physical activity and abnormal serum creatinine levels and sex difference by dose-response association.Relationship between physical activity and abnormal serum creatinine levels and sex difference by dose-response association[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(02):225-229.[doi:10.13705/j.issn.1671-6825.2017.06.081]
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基于剂量-反应关系的体力活动对血清肌酐水平的影响及其性别差异()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年02期
页码:
225-229
栏目:
应用研究
出版日期:
2018-03-20

文章信息/Info

Title:
Relationship between physical activity and abnormal serum creatinine levels and sex difference by dose-response association
作者:
许春杰1)刘晓宇2)尹素凤1)郭春月1)范红敏1)冯福民1)胡 泊1)
1)华北理工大学公共卫生学院医学统计与流行病学系 河北唐山 063210
2)华北理工大学附属开滦医院呼吸内科 河北唐山 063000
Author(s):
Relationship between physical activity and abnormal serum creatinine levels and sex difference by dose-response association
1)Department of Epidemiology and Health Statistics,School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210
2)Department of Respiratory Medicine, Kailuan General Hospital, North China University of Science and
关键词:
体力活动 血清肌酐 限制性立方样条 logistic模型
Keywords:
physical activity serum creatinine restricted cubic spline logistic regression model
分类号:
R181.3
DOI:
10.13705/j.issn.1671-6825.2017.06.081
摘要:
目的:探讨体力活动(PA)对血清肌酐(Scr)水平的影响及其性别差异。方法:采用整群抽样的方法抽取唐山某社区40~60岁的健康个体。PA的评估采用国际体力活动问卷,Scr水平采用酶法测量,男性高于106 μmol/L,女性高于97 μmol/L定义为Scr升高。应用限制性立方样条分析PA与Scr的剂量-反应关系,据此将PA分成4组; 应用非条件logistic回归分析PA与Scr的关系。结果:共2 831例(男1 157例,女1 674例)进入研究,PA与Scr呈非线性的剂量反应关系(P<0.001),按PA(单位为MET-min/周)分成4组,<129.64、129.64~288.00、>288.00~821.50、>821.50,分别为705例、709例、804例、613例。以>288.00~821.50 MET-min/周为参照组,与参照组相比,在总人群中,PA>821.50 MET-min/周与Scr升高有关, OR(95%CI)为1.474(1.132~1.919)(P<0.05); 男性中,PA<129.64或>821.50 MET-min/周均与Scr升高有关,OR(95%CI)分别为1.64(1.18~2.28)和1.59(1.14~2.22)(P均<0.05); 女性中,未发现PA水平与Scr升高的关系。结论:PA与Scr升高呈非线性关系; 高或低PA均可增加Scr异常的风险,但仅见于男性。
Abstract:
Aim: To explore the relationship between physical activity(PA)and the level of serum creatinine(Scr)and sex difference.Methods: Healthy individuals between 40 to 60 years old were recuited by cluster sampling method in Tangshan city; PA was assessed by the international physical activity questionnaire; Scr was measured by enzymic method using fasting blood sample. Definition of elevated Scr was >106 μmol/L in males and >97 μmol/L in females. Restricted cubic spline analysis was used to analyze the dose-response relationship between PA and Scr, and participants were allocated into 4 groups accordingly; unconditional logistics regression analysis was used to explore the relationship between PA and elevated Scr.Results: A total of 2 381 participants(1 157 males,1 674 females)were enrolled in statistical analyses, and were allocated into 4 groups according to the level of PA(MET-min/week), <129.64, 129.64~288.00, >288.00~821.50, >821.50,and the number of participants were 705, 709, 804, and 613, respectively. Compared with reference group(>288.00~821.50)MET-min/week, participants with PA>821.50 MET-min/week had an increased risk for abnormal Scr in total,[OR(95%CI)] was 1.47(1.13-1.92)after adjusting other confounders. Compared with reference group, participants with PA<129.64 MET-min/week and PA> 821.50 MET-min/week had increased risks for elevated Scr in males,[OR(95%CI)] was 1.64(1.18-2.28), 1.59(1.14-2.22). In females, no association was found between PA and elevated Scr(P>0.05).Conclusion: PA is non-linearly associated with Scr. Higher or lower PA may both associate with an increased risk of elevated Scr in middle-aged men.

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备注/Memo

备注/Memo:
【基金项目】国家重点课题资助项目(2016YFCO900605); 河北省自然科学基金资助项目(H2016209042)
【作者简介】胡泊,通信作者,男,1976年5月生,博士,副教授,研究方向:流行病与卫生统计,E-mail:lxy_hb007@126.com
更新日期/Last Update: 2018-03-20