[1]胡桂明),陈慧萍),冯怡锟),等.CD10在良性纤维组织细胞瘤中的表达及鉴别诊断价值[J].郑州大学学报(医学版),2018,(03):347-350.[doi:10.13705/j.issn.1671-6825.2017.09.075]
 HU Guiming),CHEN Huiping),FENG Yikun),et al.Expression of CD10 in benign fibrous histiocytoma and its differential diagnostic value[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(03):347-350.[doi:10.13705/j.issn.1671-6825.2017.09.075]
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CD10在良性纤维组织细胞瘤中的表达及鉴别诊断价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年03期
页码:
347-350
栏目:
应用研究
出版日期:
2018-03-20

文章信息/Info

Title:
Expression of CD10 in benign fibrous histiocytoma and its differential diagnostic value
作者:
胡桂明1)陈慧萍2)冯怡锟1)吴会芳1)付文静1)张 敏1)任景丽1)
1)郑州大学第二附属医院病理科 郑州 450014;2)郑州市妇幼保健院病理科 郑州 450014
Author(s):
HU Guiming1) CHEN Huiping2) FENG Yikun1) WU Huifang1) FU Wenjing1) ZHANG Min1) REN Jingli1)
1)Department of Pathology, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014; 2)Department of Pathology, the Maternal and Child Health Hospital of Zhengzhou, Zhengzhou 450014
关键词:
纤维组织细胞瘤 真皮纤维瘤 CD10 诊断鉴别
Keywords:
fibrous histiocytoma dermatofibromas CD10 diagnosisdifferential
分类号:
R738.6
DOI:
10.13705/j.issn.1671-6825.2017.09.075
摘要:
目的:探讨CD10在良性纤维组织细胞瘤(BFH)和隆突性皮纤维肉瘤(DFSP)中的表达及其在BFH鉴别诊断中的应用价值。方法:采用免疫组织化学EnVision法检测80例BFH和50例DFSP组织中CD10的表达情况,同时检测常用于BFH和DFSP鉴别诊断的抗体CD68、SMA和CD34的表达。结果:CD10在BFH和DFSP中的阳性表达率分别为85.0%(68/80)和16.0%(8/50),CD34在BFH和DFSP中的阳性表达率分别为28.8%(23/80)和88.0%(44/50),差异均有统计学意义(P<0.05); CD68与SMA在两种组织中的表达差异均无统计学意义(P>0.05)。CD10在BFH诊断中的灵敏度和特异度分别为85%和84%。结论:CD10可作为BFH诊断的标志物,用于BFH与DFSP鉴别诊断。
Abstract:
Aim: To investigate the expression of CD10 in benign fibrous histiocytoma(BFH)and dermatofibrosarcoma protuberans(DFSP), as well as its application in the differential diagnosis.Methods: The expressions of CD10, CD68, SMA and CD34 in 80 cases of BFH and 50 cases of DFSP were evaluated by immunohistochemical EnVision method.Results: The expression rate of CD10 in BFH was 85.0%(68/80)and that in DFSP was 16.0%(8/50),and the difference was significant(P<0.05). The expression rate of CD34 was 28.8%(23/80)in BFH and 88.0%(44/50)in DFSP, respectively, and the difference was significant(P<0.05). There was no statistical difference in the expression of CD68 or SMA between BFH and DFSP(P>0.05). CD10 has a high sensitivity(85%)and specificity(84%)in diagnosis of BFH.Conclusion: CD10 may be a useful marker to diagnose BFH, and it can be used in the differential diagnosis of BFH and DFSP.

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备注/Memo

备注/Memo:
【基金项目】河南省医学科技攻关普通项目(201503099)
【作者简介】任景丽,通信作者,女,1964年3月生,博士,教授,研究方向:家族性结直肠癌的发病机制,E-mail:jingliren123002@126.com
更新日期/Last Update: 2018-05-20