[1]袁帅芳),李辉东),张 培),等.高血压伴阻塞性睡眠呼吸暂停低通气综合征患者发生左室肥厚的危险因素分析[J].郑州大学学报(医学版),2018,(03):385-388.[doi:10.13705/j.issn.1671-6825.2018.01.109]
 YUAN Shuaifang),LI Huidong),ZHANG Pei),et al.Risk factor analysis of left ventricular hypertrophy in patients with hypertension and obstructive sleep apnea-hypopnea syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(03):385-388.[doi:10.13705/j.issn.1671-6825.2018.01.109]
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高血压伴阻塞性睡眠呼吸暂停低通气综合征患者发生左室肥厚的危险因素分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年03期
页码:
385-388
栏目:
应用研究
出版日期:
2018-03-20

文章信息/Info

Title:
Risk factor analysis of left ventricular hypertrophy in patients with hypertension and obstructive sleep apnea-hypopnea syndrome
作者:
袁帅芳1)李辉东1)张 培1)刘 敏12)
1)郑州大学第二附属医院心血管内科 郑州 450014 2)河南省人民医院高血压科 郑州 450003
Author(s):
YUAN Shuaifang1)LI Huidong1)ZHANG Pei1)LIU Min12)
1)Department of Cardiovascular Medicine, the Second Affiliated Hospital, Zhengzhou University,Zhengzhou 450014;2)Hypertension Department, Henan Provincial People's Hospital, Zhengzhou 450003
关键词:
高血压 阻塞性睡眠呼吸暂停低通气综合征 血压变异性 左室肥厚
Keywords:
hypertension obstructive sleep apnea-hypopnea syndrome blood pressure variability left ventricle hypertrophy
分类号:
R563.9
DOI:
10.13705/j.issn.1671-6825.2018.01.109
摘要:
目的:探讨高血压伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者发生左室肥厚的危险因素。方法:选取高血压伴OSAHS患者347例,根据左室质量指数(LVMI,g/m2)≥115(男)或≥95(女)将患者分为左室肥厚组(n=45)和对照组(n=302)。比较两组患者一般临床资料、睡眠呼吸暂停低通气指数(AHI)、血压变异性等指标,采用logistic回归分析高血压伴OSAHS患者发生左室肥厚的影响因素。结果:高血压伴OSAHS人群中,左室肥厚组女性患者比例、AHI、24 h收缩压变异性均高于对照组(P均<0.05)。将以上因素纳入logistic回归,结果显示:性别、AHI、24 h收缩压变异性为LVMI的影响因素,OR(95%CI)分别为0.323(0.136~0.770)、1.036(1.019~1.052)、1.228(1.117~1.350)。结论:高血压伴OSAHS患者中,女性、高AHI及24 h收缩压变异性为左室肥厚的危险因素。
Abstract:
Aim: To explore the risk factors of left ventricle hypertrophy in patients with hypertension and obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods: A total of 347 patients with hypertension and OSAHS were enrolled,and divided into two groups according to LVMI(g/m2)≥115(male)or ≥95(female), left ventricular hypertrophy group(n=45)and control group(n=302). General clinical data, AHI, blood pressure variability, etc were compared. The risk factors of left ventricular hypertrophy were analyzed by logistic regression.Results: The percentage of female patients, AHI and 24 h systolic pressure variability in left ventricular hypertrophy group were higher than those in control group(P<0.05). Logistic regression analysis of the above factors showed that gender,AHI,and 24 h systolic pressure variability were influencing factors of left ventricular hypertrophy, and OR(95%CI) were 0.323(0.136-0.770),1.036(1.019-1.052),1.228(1.117-1.350).Conclusion: Female,high AHI and 24 h systolic pressure variability are risk factors for the left ventricular hypertrophy in patients with hypertension and OSAHS.

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备注/Memo

备注/Memo:
【作者简介】刘敏,通信作者,女,1974年4月生,博士,主任医师,研究方向:高血压的诊治,E-mail:liumin136@126.com
更新日期/Last Update: 2018-05-20