[1]杨凯丽),霍文倩),刘晓田),等.河南农村汉族人群KCNQ1基因rs2299620位点多态性与2型糖尿病的关系[J].郑州大学学报(医学版),2018,(04):421-424.[doi:10.13705/j.issn.1671-6825.2017.12.011]
 YANG Kaili),HUO Wenqian),LIU Xiaotian),et al.Association of rs2299620 of KCNQ1 gene polymorphism with type 2 diabetes mellitus in Han population from Henan rural area[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(04):421-424.[doi:10.13705/j.issn.1671-6825.2017.12.011]
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河南农村汉族人群KCNQ1基因rs2299620位点多态性与2型糖尿病的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年04期
页码:
421-424
栏目:
论著
出版日期:
2018-07-20

文章信息/Info

Title:
Association of rs2299620 of KCNQ1 gene polymorphism with type 2 diabetes mellitus in Han population from Henan rural area
作者:
杨凯丽1) 霍文倩2) 刘晓田1) 屠润琪1) 刘瑞华1) 张洪磊1) 张海庆1) 毛振兴1) 李玉倩3) 王重建1)
1)郑州大学公共卫生学院流行病学教研室 郑州 450001;2)郑州大学公共卫生学院环境卫生学教研室 郑州 450001;3)郑州大学药学院临床药理学系 郑州 450001
Author(s):
YANG Kaili1) HUO Wenqian2) LIU Xiaotian1) TU Runqi1) LIU Ruihua1) ZHANG Honglei1) ZHANG Haiqing1) MAO Zhenxing1) LI Yuqian3) WANG Chongjian1)
1)Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001; 2)Department of Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001 3)Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001
关键词:
KCNQ1基因 rs2299620 2型糖尿病 基因多态性 基因-环境交互作用
Keywords:
KCNQ1 gene rs2299620 loci type 2 diabetes mellitus polymorphism gene-environment interaction
分类号:
R587.1
DOI:
10.13705/j.issn.1671-6825.2017.12.011
摘要:
目的:探讨河南农村汉族人群中KCNQ1基因rs2299620位点多态性与2型糖尿病易感性的关联。方法:采用1GA6FA1匹配的病例对照研究设计,通过问卷调查获得522对研究对象的基本情况; rs2299620位点基因型采用Taqman荧光探针分析获得。采用条件logistic回归分析rs2299620位点多态性与2型糖尿病易感性的关联; 采用MDR模型和叉生分析探讨基因-环境的交互作用。结果:调整多种环境因素后,rs2299620位点CC和(TC+CC)基因型与河南农村汉族人群2型糖尿病易感性增加有关联,OR(95%CI)分别为1.74(1.11~2.75)和1.56(1.02~2.40)。以等位基因T为参照,等位基因C增加2型糖尿病的易感性,OR(95%CI)为1.16(1.04~1.29)。进一步分析显示,在2型糖尿病易感性的影响因素中rs2299620位点多态性与体质指数存在交互作用,OR(95%CI)为1.04(1.02~1.08)。结论:KCNQ1基因rs2299620位点多态性与河南农村汉族人群2型糖尿病易感性有关联,且该位点多态性与体质指数对2型糖尿病的发生具有交互作用。
Abstract:
Aim: To explore the association between KCNQ1 gene rs2299620 loci polymorphism and the prevalence of type 2 diabetes mellitus(T2DM)in rural Han population from Henan Province.Methods: A 1GA6FA1 case-control study was conducted, and the basic characteristics of the subjects were collected through a standardized questionnaire. Taqman fluorescence probe was used to analyze the genotype of rs2299620 loci. The conditional logistic regression analysis was built to estimate the relationship between rs2299620 loci polymorphism and T2DM. The multifactor dimensionality reduction(MDR)model and crossover analysis were used to estimate the interaction between gene and environment factors.Results: The genotype CC and TC+CC of rs2299620 loci increased the risk of T2DM after adjusting environments factors, and the corresponding OR(95%CI) were 1.74(1.11-2.75)and 1.56(1.02-2.40), respectively. Compared with T allele in rs2299620 loci, the OR(95%CI) of C allele for T2DM was 1.16(1.04-1.29). The interaction between rs2299620 locus and body mass index on the susceptibility of T2DM was observed, and OR(95%CI) was 1.04(1.02-1.08).Conclusion: The rs2299620 loci polymorphism of KCNQ1 gene is associated with the susceptibility of T2DM in rural Han population from Henan Province, and there is interaction between rs2299620 loci polymorphism and body mass index.

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备注/Memo

备注/Memo:
【基金项目】国家重点研发计划重点专项(2016YFC0900803); 国家自然科学基金项目(81573243,81602925); 河南省科技创新人才支持计划项目(164100510021); 河南省高校科技创新人才支持计划项目(14HASTIT035); 河南省医学科技攻关计划项目(201401002,201403002)
【作者简介】王重建,通信作者,男,1977年10月生,博士,教授,研究方向:心血管代谢性疾病,E-mail: tjwcj2005@126.com
更新日期/Last Update: 2018-06-20