[1]张洪磊),李玉倩),张 霞),等.ZPR1基因rs603446位点多态性与河南汉族人群血脂异常遗传易感性的关系[J].郑州大学学报(医学版),2018,(04):432-436.[doi:10.13705/j.issn.1671-6825.2017.12.092]
 ZHANG Honglei),LI Yuqian),ZHANG Xia),et al.Association of ZPR1 gene rs603446 locus polymorphism with susceptibility of dyslipidemia in Henan Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(04):432-436.[doi:10.13705/j.issn.1671-6825.2017.12.092]
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ZPR1基因rs603446位点多态性与河南汉族人群血脂异常遗传易感性的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年04期
页码:
432-436
栏目:
论著
出版日期:
2018-07-20

文章信息/Info

Title:
Association of ZPR1 gene rs603446 locus polymorphism with susceptibility of dyslipidemia in Henan Han population
作者:
张洪磊1)李玉倩2)张 霞1)刘晓田1)屠润琪1)刘瑞华1)杨凯丽1)毛振兴1)张功员1)王重建1)
1)郑州大学公共卫生学院流行病学教研室 郑州 450001;2)郑州大学药学院临床药理学系 郑州 450001
Author(s):
ZHANG Honglei1) LI Yuqian2) ZHANG Xia1) LIU Xiaotian1)TU Runqi1) LIU Ruihua1) YANG Kaili1) MAO Zhenxing1) ZHANG Gongyuan1) WANG Chongjian1)
1)Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001; 2)Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001
关键词:
血脂异常 锌指蛋白 基因多态性 交互作用 河南汉族人群
Keywords:
dyslipidemia ZPR1 gene polymorphism interaction Henan Han population
分类号:
R181.33
DOI:
10.13705/j.issn.1671-6825.2017.12.092
摘要:
目的:研究河南汉族人群锌指蛋白(ZPR1)rs603446位点多态性与血脂异常的关联。方法:从河南农村队列研究中抽取916例血脂异常患者,根据年龄、性别进行1GA6FA1匹配,选取916例血脂正常者作为对照组; 采用2×48位SNPscanTM高通量SNP分型技术获取人群rs603446位点的基因型; 条件logistic回归分析位点多态性与血脂异常的关联强度; 多因子降维法(MDR)结合叉生分析评估基因与环境的交互作用。结果:血脂异常组和正常组ZPR1 rs603446位点3种基因型(CC、CT、TT)分布频率差异有统计学意义(P=0.046)。调整相关环境因素后,ZPR1基因rs603446位点突变基因型CT+TT携带者可降低血脂异常的发生(调整OR=0.695,95%CI=0.553~0.872); 交互作用分析结果显示,rs603446位点与吸烟具有相加交互作用(调整OR=0.516,95%CI=0.370~0.663),与体力活动具有相乘交互作用(调整OR=0.873,95%CI=0.819~0.930)。结论:ZPR1基因 rs603446多态性与血脂异常存在关联,且吸烟、体力活动对血脂异常的发病具有交互作用。
Abstract:
Aim: To investigate the association of zinc finger(ZPR1)gene rs603446 locus polymorphism and the susceptibility of dyslipidemia(DYS)in Henan Han population.Methods: A total of 916 DYS subjects and 916 controls based on 1:1 matching were collected from the Henan Rural Cohort study; the single nucleotide polymorphism of ZPR1 gene rs603446 was detected using a custom-by-design 2×48-Plex SNPscanTM Kit; conditional logistic regression was performed to evaluate the association between ZPR1 gene polymorphism and DYS; multifactor dimensionality reduction(MDR)model and crossover analysis were used to evaluate the interaction between gene and environment.Results: Three genotypes(CC, CT and TT)frequency of ZPR1 gene rs603446 between DYS group and control group had significant difference(P=0.046). The data showed that genotype(CT+TT)of ZPR1 gene rs603446 locus polymorphism decreased the risk of DYS after adjusting environmental risk factors(adjusted OR=0.695, 95%CI:0.553-0.872). Interaction analysis demonstrated that there was additive interaction between rs603446 and smoking(adjusted OR=0.516, 95%CI:0.370-0.663), and multiplicative interaction between rs603446 and physical activity on the susceptibility of DYS was found(adjusted OR=0.873, 95%CI:0.819-0.930).Conclusion: ZPR1 gene rs603446 locus polymorphism is associated with the susceptibility of DYS. The interaction between gene and smoking, gene and physical activity is found on the susceptibility of DYS.

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金资助项目(81573243,81602925); 国家重点研发计划“精准医学研究”重点专项(2016YFC0900803); 河南省科技创新人才支持计划项目(164100510021); 河南省高校科技创新人才支持计划项目(14HASTIT035); 河南省医学科技攻关计划项目(201401002,201403002); 郑州大学高端人才支持计划项目(ZDGD13001)
【作者简介】王重建,通信作者,男,1977年10月生,博士,教授,研究方向:心血管代谢性疾病,E-
更新日期/Last Update: 2018-06-20