[1]赵冬梅,耿旭景,谭 丽,等.多囊卵巢综合征个体化调整内分泌治疗疗效观察[J].郑州大学学报(医学版),2018,(04):466-469.[doi:10.13705/j.issn.1671-6825.2017.12.009]
 ZHAO Dongmei,GENG Xujing,TAN Li,et al.Efficacy of individualized adjustment of endocrine in patients with polycystic ovary syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(04):466-469.[doi:10.13705/j.issn.1671-6825.2017.12.009]
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多囊卵巢综合征个体化调整内分泌治疗疗效观察()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年04期
页码:
466-469
栏目:
应用研究
出版日期:
2018-07-20

文章信息/Info

Title:
Efficacy of individualized adjustment of endocrine in patients with polycystic ovary syndrome
作者:
赵冬梅耿旭景谭 丽马丽影张 丹项云改
郑州大学第二附属医院生殖中心 郑州 450014
Author(s):
ZHAO Dongmei GENG Xujing TAN Li MA Liying ZHANG Dan XIANG Yungai
Reproductive Center, the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014
关键词:
多囊卵巢综合征 内分泌 个体化策略
Keywords:
polycystic ovary syndrome endocrine individualized strategy
分类号:
R711.75
DOI:
10.13705/j.issn.1671-6825.2017.12.009
摘要:
目的:探讨个体化调整内分泌策略治疗多囊卵巢综合征(PCOS)的临床疗效。方法:根据睾酮(T)、促黄体生成素(LH)水平将220例PCOS患者分为3组。A1组(基础状态血清T、LH水平同时升高)50例,给予炔雌醇环丙孕酮(达英-35)2个周期、去氧孕烯炔雌醇(妈富隆)1个周期口服; A2组(基础状态血清T水平升高)40例,给予达英-35 1个周期、屈螺酮炔雌醇(优思明)2个周期口服; A3组(基础状态血清LH水平升高)130例,行达英-35 1个周期、妈富隆2个周期口服; 然后促排卵。结果:A1组调整内分泌后血清T、LH、FSH、LH/FSH较调整前下降(P<0.05),A2组调整后血清T、LH/FSH较调整前下降(P<0.05),A3组调整后血清T、LH、LH/FSH较调整前下降(P<0.05)。3组排卵率、有效率、不良反应发生率差异无统计学意义(P>0.05)。220例总体排卵率达60.0%,总体有效率达54.5%,总体不良反应发生率为5.5%。结论:个体化调整内分泌能明显改善PCOS患者体内内分泌紊乱状态,提高排卵率及临床妊娠率,安全性较高。
Abstract:
Aim: To explore the efficacy of individualized adjustment of endocrine in the treatment of polycystic ovary syndrome(PCOS).Methods: A total of 220 patients with PCOS were collected, and divided into A1, A2 and A3 groups according to the levels of testosterone(T)and luteinizing hormone(LH)before treatment. A1 group(high level of T and LH,n=50)was given Diane-35 for 2 cycles and Marvelon for 1 cycle, A2 group(high level of T,n=40)was given Diane-35 for 1 cycle and Yasmin for 2 cycles, and A3 group(high level of LH,n=130)was given Diane-35 for 1 cycle and Marvelon for 2 cycles. Then ovulation induction was performed.Results:After the adjustment,serum T, LH, FSH and LH/FSH in A1 group decreased(P<0.05); serum T and LH/FSH in A2 group decreased(P<0.05); serum T, LH and LH/FSH in A3 group decreased significantly(P<0.05). The ovulation rate,effective rate, and the incidence of adverse reactions among the three groups had no statistical differences(P>0.05). The total ovulation rate,effective rate, and the incidence of adverse reactions of the 220 cases were 60.0%,54.5% and 5.5%.Conclusion: Individualized adjustment of endocrine can relieve endocrine disorder situation of patients with PCOS, and increase the ovulation rate and clinical pregnancy rate, with high safety.

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备注/Memo

备注/Memo:
【基金项目】河南省医学科技攻关计划项目(201303085)
【作者简介】赵冬梅,第一作者,女,1962年12月生,硕士,主任医师,研究方向:生殖医学,E-mail:zhaodongomei6@126.com
更新日期/Last Update: 2018-06-20