[1]施小晴),王俊杰),彭梦乐),等.VWC2L基因rs13428663多态性与中国汉族扩张型心肌病易感性的关系[J].郑州大学学报(医学版),2018,(05):634-637.[doi:10.13705/j.issn.1671-6825.2018.01.003]
 SHI Xiaoqing),WANG Junjie),PENG Mengle),et al.Association between rs13428663 polymorphism of VWC2L gene and risk of dilated cardiomyopathy in Chinese Han population[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(05):634-637.[doi:10.13705/j.issn.1671-6825.2018.01.003]
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VWC2L基因rs13428663多态性与中国汉族扩张型心肌病易感性的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年05期
页码:
634-637
栏目:
应用研究
出版日期:
2018-09-20

文章信息/Info

Title:
Association between rs13428663 polymorphism of VWC2L gene and risk of dilated cardiomyopathy in Chinese Han population
作者:
施小晴1)王俊杰2)彭梦乐3)李冰洁1)袁莹莹1)秦东春1)
1)郑州大学第一附属医院检验科 郑州 450052;2)淮滨县第一人民医院心内科 河南信阳 464400;3)河南省直第三人民医院检验科 郑州450006
Author(s):
SHI Xiaoqing1)WANG Junjie2)PENG Mengle3)LI Bingjie1)YUAN Yingying1)QIN Dongchun1)
1)Department of Clinical Laboratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;2)Department of Cardiovascular Medicine,Huaibin First People's Hospital,Xinyang,Henan 464400;3)Department of Clinical Laboratory,the Third People's Hospital of Henan Province,Zhengzhou 450006
关键词:
VWC2L基因 扩张型心肌病 基因多态性 中国汉族
Keywords:
VWC2L gene dilated cardiomyopathy genetic polymorphism Chinese Han population
分类号:
R542.2
DOI:
10.13705/j.issn.1671-6825.2018.01.003
摘要:
目的:评估VWC2L基因rs13428663和HSPB7基因rs1739843与中国汉族扩张型心肌病(DCM)人群易感性的关系。方法:采用基质辅助激光解析电离飞行时间质谱进行基因分型,对中国汉族人群(593例病例和513例对照)进行分析,以探讨rs13428663和rs1739843与DCM的关系。结果:VWC2L基因rs13428663位点 G 等位基因频率在病例组和对照组间比较差异有统计学意义(OR=1.231,95%CI=1.007~1.504,P=0.042)。此外,该位点在加性模型(OR=1.231,95%CI=1.007~1.504,P=0.042)与DCM易感性有关。结论:VWC2L基因rs13428663多态性可能与中国汉族人群DCM易感性有关。
Abstract:
Aim: To evaluate the association between rs13428663 in VWC2L gene or rs1739843 in HSPB7 gene with dilated cardiomyopathy(DCM)in the Chinese Han population.Methods:A total of 593 DCM patients and 513 controls were involved in the study, genotyping was performed by matrix-assisted laser desorption/ionization time of flight mass spectrometry. The prevalence of polymorphisms of rs13428663 and rs1739843 in the Chinese Han population with DCM was explored.Results: G allele frequency on rs13428663 of VWC2L had statistical difference between DCM group and control group(OR=1.231,95%CI=1.007-1.504,P=0.042).Besides, an association between rs13428663 and risk of DCM was observed in the additive model(OR=1.231,95%CI=1.007-1.504,P=0.042).Conclusion: There may be an association between rs13428663 polymorphism of VWC2L gene and risk of DCM in Chinese Han population.

参考文献/References:

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备注/Memo

备注/Memo:
【基金项目】河南省科技攻关基金资助项目(172102310077)
【作者简介】秦东春,通信作者,男,1963年12月生,博士,教授,主任技师,研究方向:肿瘤及自身免疫病,E-mail:qindongchun@zzu.edu.cn
更新日期/Last Update: 2018-09-20