[1]陈小梦,闫 昊,左子欣,等.癌组织中MMP-9的表达对食管癌诊断价值的meta分析[J].郑州大学学报(医学版),2018,(05):642-647.[doi:10.13705/j.issn.1671-6825.2018.02.011]
 CHEN Xiaomeng,YAN Hao,ZUO Zixin,et al.MMP-9 as a biomarker for esophageal cancer: a meta-analysis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(05):642-647.[doi:10.13705/j.issn.1671-6825.2018.02.011]
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癌组织中MMP-9的表达对食管癌诊断价值的meta分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年05期
页码:
642-647
栏目:
应用研究
出版日期:
2018-09-20

文章信息/Info

Title:
MMP-9 as a biomarker for esophageal cancer: a meta-analysis
作者:
陈小梦闫 昊左子欣孙亚新孙 沛徐 霞杜 娟
郑州大学药学院 郑州 450001
Author(s):
CHEN XiaomengYAN HaoZUO ZixinSUN YaxinSUN PeiXU XiaDU Juan
College of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001
关键词:
MMP-9 食管癌 诊断 meta分析
Keywords:
MMP-9 esophageal cancer diagnosis meta-analysis
分类号:
R735.1
DOI:
10.13705/j.issn.1671-6825.2018.02.011
摘要:
目的:探讨MMP-9作为食管癌生物标志物的可靠性。方法:计算机检索Web of Knowledge、PubMed、Cochrane Library、中文科技期刊全文数据库(VIP)、万方数据库及中国知网(CNKI)等数据库,搜集从建库至2017年12月的相关文献,按照纳入与排除标准筛选文献,最终纳入文献14篇,其中食管癌847例,对照516例,应用StataMP 14和MetaDisc 1.4软件对纳入文献进行诊断性试验meta分析。结果:Meta分析结果显示,MMP-9在食管癌组织中的表达高于癌旁组织。MMP-9诊断食管癌的灵敏度为0.73(95%CI 0.68~0.77),特异度为0.82(95%CI 0.73~0.89),阳性似然比为4.1(95%CI 2.6~6.5),阴性似然比为0.33(95%CI 0.27~0.40),诊断优势比为12(95%CI 7~23),SROC曲线下面积为0.80(95%CI 0.77~0.84)。结论:MMP-9在食管癌组织中的表达升高,可作为诊断食管癌的辅助参考指标之一。
Abstract:
Aim: To investigate the reliability of MMP-9 as biomarker of esophageal cancer.Methods: The databases of Web of Knowledge, PubMed, Cochrane Library, VIP, Wanfang Database and CNKI were searched by computer, and the related documents were collected till December 2017. According to inclusion and exclusion standards of screening literature, 14 articles finally were chosen which included 847 cases of esophageal cancer and 516 cases of control. StataMP 14 and MetaDisc 1.4 were used in meta analysis of the literature diagnostic accuracy.Results: Meta-analysis showed that the expression of MMP-9 in esophageal cancer tissue was higher than that in paracancerous tissue. The diagnostic accuracy of MMP-9 was 0.73(95%CI 0.68-0.77), specificity was 0.82(95%CI 0.73-0.89). The positive likelihood ratio was 4.1(95%CI 2.6-6.5), the negative likelihood ratio was 0.33(95%CI 0.27-0.40),and the diagnostic odds ratio was 12(95%CI 7-23). The area under the curve in SROC plot was 0.80(95%CI 0.77-0.84).Conclusion: The expression of MMP-9 in esophageal cancer tissue is increased and MMP-9 could be used as one of the assistant reference indexes for the diagnosis of esophageal cancer.

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备注/Memo

备注/Memo:
【作者简介】徐霞,通信作者,女,1965年4月生,博士,教授,研究方向:药物分析,E-mail:xuxia@zzu.edu.cn; 杜娟,通信作者,女,1966年10月生,硕士,副教授,研究方向:药事管理,E-mail:dujuan2004@zzu.edu.cn
更新日期/Last Update: 2018-09-20