[1]刘冬雨,刘 璐,张 颖,等.C3肾小球病患者血清MASP2、MASP3水平检测[J].郑州大学学报(医学版),2018,(06):800-804.[doi:10.13705/j.issn.1671-6825.2018.03.090]
 LIU Dongyu,LIU Lu,ZHANG Ying,et al.Determination of serum MASP2 and MASP3 in patients with C3 glomerulopathy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(06):800-804.[doi:10.13705/j.issn.1671-6825.2018.03.090]
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C3肾小球病患者血清MASP2、MASP3水平检测()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年06期
页码:
800-804
栏目:
应用研究
出版日期:
2018-11-20

文章信息/Info

Title:
Determination of serum MASP2 and MASP3 in patients with C3 glomerulopathy
作者:
刘冬雨刘 璐张 颖邢国兰
郑州大学第一附属医院肾脏内科 郑州 450052
Author(s):
LIU DongyuLIU LuZHANG YingXING Guolan
Department of Nephrology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
C3肾小球病 甘露糖结合丝氨酸蛋白酶 补体
Keywords:
C3 glomerulopathy mannan-binding lectin serine peotease complement
分类号:
R692.3
DOI:
10.13705/j.issn.1671-6825.2018.03.090
摘要:
目的:探讨甘露糖结合凝集素(MBL)途径相关蛋白甘露糖结合丝氨酸蛋白酶-2(MASP2)、MASP3在C3肾小球病(C3G)患者血清中的表达及其在C3G发病中的作用。方法:回顾性分析15例C3G患者(14例C3肾小球肾炎和1例致密物沉积病)的临床资料,用ELISA测定肾活检当天血清MASP2、MASP3水平,分析MASP2、MASP3与临床及病理指标的关系。10名健康志愿者为对照。结果:C3G患者血清MASP2、MASP3水平均高于对照组(P<0.05)。血清MASP2、MASP3水平与肾小球滤过率及血清补体C3水平均无关(P>0.05),血清MASP3水平与24 h尿蛋白定量呈正相关(r=0.563,P=0.036)。C3荧光强度高或有基底膜内电子致密物沉积的C3G患者血清MASP2水平较低(P<0.05)。结论:C3G患者尿蛋白量随着血清MASP3的升高而升高,提示MBL途径可能参与该病的发生发展; MASP2水平的异常降低可能与C3G病理损伤程度加重有关。
Abstract:
Aim:To investigate the serum mannan-binding lectin serine protease-2(MASP2),MASP3 of patients with C3 glomerulopathy(C3G)and their roles in the pathogenesis of C3G.Methods:The clinical and pathological data of 15 patients with C3G(14 cases of C3 glomerulonephritis and 1 case of dense deposit disease)were collected.Ten volunteers were chosen as healthy control.The levels of serum MASP2 and MASP3 of the 2 groups were detected by ELISA on the day of renal biopsy. The relationship between MASP2,MASP3 with the clinical and pathological parameters was evaluated.Results:Serum MASP2 and MASP3 in patients with C3G were generally higher than those in healthy controls(P<0.05). There was no significant correlation between serum MASP2,MASP3 with serum C3 or estimated glomerular filtration rate(P>0.05); serum MASP3 was positively correlated with 24-hour urinary protein(r=0.563,P=0.036). The serum MASP2 level was lower in the C3G patients with higher C3 deposition intensity or presence of basement membrane deposition(P<0.05).Conclusion:Mannan-binding lectin pathway may be involved in the pathogenesis of C3G.The abnormal decrease of MASP2 level may be related to the worsening of pathological damage of C3G.

参考文献/References:

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备注/Memo

备注/Memo:
【作者简介】邢国兰,通信作者,女,1965年8月生,博士,主任医师,研究方向:慢性肾脏病的防治,E-mail:xgl@zzu.edu.cn
更新日期/Last Update: 2018-11-20