[1]朱艳芳),谢新立),于艳霞),等.18F-FDG PET/CT显像SUVmax对不同病理分型肾细胞癌的鉴别价值[J].郑州大学学报(医学版),2018,(06):807-811.[doi:10.13705/j.issn.1671-6825.2018.04.086]
 ZHU Yanfang),XIE Xinli),YU Yanxia),et al.Clinical application value of different pathological classifications of renal cell carcinoma using the SUVmax of 18F-FDG PET/CT[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(06):807-811.[doi:10.13705/j.issn.1671-6825.2018.04.086]
点击复制

18F-FDG PET/CT显像SUVmax对不同病理分型肾细胞癌的鉴别价值()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年06期
页码:
807-811
栏目:
应用研究
出版日期:
2018-11-20

文章信息/Info

Title:
Clinical application value of different pathological classifications of renal cell carcinoma using the SUVmax of 18F-FDG PET/CT
作者:
朱艳芳1)谢新立1)于艳霞1)李道明2)许莎莎1)阮 翘1)
1)郑州大学第一附属医院核医学科 郑州 450052;2)郑州大学第一附属医院病理科 郑州 450052
Author(s):
ZHU Yanfang1)XIE Xinli1)YU Yanxia1)LI Daoming2)XU Shasha1)RUAN Qiao1)
1)Deparment of Nuclear Medicine,the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052; 2)Deparment of Pathology,the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
CTPET 标准摄取最大值 肾细胞癌
Keywords:
computed tomographypositron emission tomography standard uptake maximum renal cell carcinoma
分类号:
R445.6; R737.11
DOI:
10.13705/j.issn.1671-6825.2018.04.086
摘要:
目的: 探讨应用18F-FDG PET/CT显像最大标准摄取值(SUVmax)鉴别肾细胞癌(RCC)不同病理分型的临床应用价值。方法:回顾性分析经手术或组织活检病理确诊为RCC的87例患者(其中肾透明细胞癌63例、肾乳头状癌13例、嫌色细胞癌11例)PET/CT显像资料,经采集图像信息获取肿瘤病灶的SUVmax值和肿瘤最长径,比较不同病理分型肾癌(肾透明细胞癌、肾乳头状癌、嫌色细胞癌)之间SUVmax的差异、不同Fuhrman分级以及不同临床分期(有无远处转移)肾透明细胞癌的SUVmax的差异。结果: 不同病理分型的RCC患者SUVmax差异有统计学意义(肾乳头状癌>肾透明细胞癌>嫌色细胞癌,P<0.05); 低级别肾透明细胞癌与高级别肾透明细胞癌SUVmax及最长径差异有统计学意义(P<0.05); 合并转移的肾透明细胞癌与无转移的肾透明细胞癌SUVmax及最长径差异有统计学意义(P<0.05)。结论:18F-FDG PET/CT显像SUVmax对鉴别RCC的病理分型、肾透明细胞癌分级及评估临床分期及预后有重要的指导意义。
Abstract:
Aim:To explore the clinical application value of different pathological classifications of renal cell carcinoma(RCC)using the maximum standard uptake value(SUVmax)of 18F-FDG PET/CT.Methods:Retrospective study was used to analyze the PET/CT imaging data of 87 patients with RCC(63 cases of renal clear cell carcinoma, 13 cases of papillary carcinoma, and 11 cases of chromophobe carcinoma)confirmed by surgery or tissue biopsy was performed. The acquired image information was used to obtain the SUVmax and the longest diameter of tumor lesions. The SUVmax of RCC with different pathological types(renal clear cell carcinoma, papillary carcinoma, chromophobe carcinoma),different Fuhrman grades and different clinical grades(with or without distant metastasis)were compared.Results:The SUVmax in RCC patients with different pathological types had statistical significance(papillary carcinoma>renal clear cell carcinoma>chromophobe carcinoma,P<0.05); the SUVmax and the longest diameter had statistical different between low-grade renal clear cell carcinoma and high-grade renal clear cell carcinoma(P<0.05); the SUVmax and the longest diameter had significant difference between metastatic renal clear cell carcinoma and the non-metastatic(P<0.05).Conclusion:The SUVmax of 18F-FDG PET/CT imaging has important guiding significance for the differentiation of RCC pathological classification, the classification of renal clear cell carcinoma, and the evaluation of clinical stage and prognosis.

参考文献/References:

[1] SIEGEL RL,MILLER KD,FEDEWA SA,et al.Colorectal cancer statistics,2017[J].CA Cancer J Clin,2017,64(2):104
[2] STEFFENS S,JANSSEN M,ROOS FC,et al.Incidence and long-term prognosis of papillary compared to clear cell renal cell carcinoma: a multicentre study[J].Eur J Cancer,2012,48(15):2347
[3] VOLPE A,NOVARA G,ANTONELLI A,et al.Chromophobe renal cell carcinoma(RCC): oncological outcomes and prognostic factors in a large multicentre series[J].BJU Int,2012,110(1):76
[4] KHANDANI AH,COWEY CL,MOORE DT,et al.Primary renal cell carcinoma: relationship between 18F-FDG uptake and response to neoadjuvant sorafenib[J].Nucl Med Commun,2012,33(9):967
[5] TAKAHASHI M,KUME H,KOYAMA K,et al.Preoperative evaluation of renal cell carcinoma by using 18F-FDG PET/CT[J].Clin Nucl Med,2015,40(12):936
[6] SUGANUMA N,SEGADE F,MATSUZU K,et al.Differential expression of facilitative glucose transporters in normal and tumour kidney tissues[J].BJU Int,2007,99(5):1143
[7] LIDGREN A,BERGH A,GRANKVIST K,et al.Glucose transporter-1 expression in renal cell carcinoma and its correlation with hypoxia inducible factor-1α[J].BJU Int,2008,101(4):480
[8] 熊升远,林毅,阮同德,等.葡萄糖转运因子1蛋白在肾癌组织中的表达及意义[J].山东医药,2012,52(23):44
[9] 邸丽娟,王荣福,张建华,等.18F-FDG PET/CT半定量参数SUVmax对肾透明细胞癌分级分期的预测价值[J].肿瘤学杂志,2017,10(4):295
[10] POLAT EC,OTUNCTEMUR A,OZBEK E,et al.Standardized uptake values highly correlate with tumor size and Fuhrman grade in patients with clear cell renal cell carcinoma[J].Asian Pac J Cancer Prev,2014,15(18):7821
[11] NODA Y,KANEMATSU M,GOSHIMA S,et al.18-F fluorodeoxyglucose uptake in positron emission tomography as a pathological grade predictor for renal clear cell carcinomas[J].Eur Radiol,2015,25(10):3009[12] 祝安惠,张卫方. 18F-FDG PET/CT诊断肾细胞癌[J].中国医学影像技术,2017,33(4):571
[13] NAMURA K,MINAMIMOTO R,YAO M,et al.Impact of maximum standardized uptake value(SUVmax)evaluated by 18-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography(18F-FDG-PET/CT)on survival for patients with advanced renal cell carcinoma: a preliminary report[J].BMC Cancer,2010,10:667

相似文献/References:

[1]武天奎.结节性硬化16例CT和MRI诊断[J].郑州大学学报(医学版),2010,(03):522.
[2]革化民,崔静,刘保平#,等.骨显像和CT诊断多发性骨髓瘤骨质破坏的比较革化民[J].郑州大学学报(医学版),2010,(06):1031.
[3]李莹,任翠萍#,程敬亮,等.骨肉瘤54例影像学表现[J].郑州大学学报(医学版),2011,(05):791.
[4]焦建国,孙珂#.全身骨显像与CT对儿童神经母细胞瘤骨转移的诊断价值[J].郑州大学学报(医学版),2012,(04):540.
 JIAO Jianguo,SUN Ke.Comparison of whole body bone scan and CT in diagnosing bone metastases of neuroblastoma in children[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(06):540.
[5]王天佑,郭华,高剑波.巨淋巴结增生症的CT表现[J].郑州大学学报(医学版),2012,(04):574.
[6]李辉)△,姜春霞),宁培刚),等.肺内孤立结节的高分辨CT征象诊断价值[J].郑州大学学报(医学版),2014,(06):872.
 LI Hui),JIANG Chunxia),NING Peigang),et al.Diagnostic value of sign of solitary pulmonary nodule in highresolution CT[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(06):872.

备注/Memo

备注/Memo:
【作者简介】阮翘,通信作者,女,1962年10月生,本科,主任医师,研究方向:心血管及肿瘤核医学,E-mail:ruanqiao-6@126.com
更新日期/Last Update: 2018-11-20