[1]季莹莹,汤建民,王丰云,等.单核细胞/高密度脂蛋白胆固醇比值与ST段抬高型急性心肌梗死患者梗死相关动脉自发再通的关系[J].郑州大学学报(医学版),2019,(01):77-81.[doi:10.13705/j.issn.1671-6825.2018.05.009]
 JI Yingying,TANG Jianmin,WANG Fengyun,et al.Association of monocyte to high density lipoprotein cholesterol ratio with spontaneous recanalization of infarct-related artery in patients with ST segment elevation acute myocardial infarction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(01):77-81.[doi:10.13705/j.issn.1671-6825.2018.05.009]
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单核细胞/高密度脂蛋白胆固醇比值与ST段抬高型急性心肌梗死患者梗死相关动脉自发再通的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年01期
页码:
77-81
栏目:
应用研究
出版日期:
2019-01-20

文章信息/Info

Title:
Association of monocyte to high density lipoprotein cholesterol ratio with spontaneous recanalization of infarct-related artery in patients with ST segment elevation acute myocardial infarction
作者:
季莹莹 汤建民王丰云杨雁华 宿东升 朱银川 赵一品 王顺利 来桂颗
郑州大学第二附属医院心内科 郑州 450014
Author(s):
JI YingyingTANG JianminWANG FengyunYANG YanhuaSU DongshengZHU YinchuanZHAO YipinWANG ShunliLAI Guike
Department of Cardiology,the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014
关键词:
单核细胞/高密度脂蛋白胆固醇比值 ST段抬高型急性心肌梗死 自发再通
Keywords:
monocyte to high density lipoprotein cholestrol ratio ST segment elevation acute myocardial infarction spontaneous recanalization
分类号:
R541.7
DOI:
10.13705/j.issn.1671-6825.2018.05.009
摘要:
目的:研究单核细胞/高密度脂蛋白胆固醇比值(MHR)与ST段抬高型急性心肌梗死(STEMI)患者梗死相关动脉(IRA)自发再通的相关性。方法:急诊行经皮冠状动脉造影(CAG)的STEMI患者155例,根据术中心肌梗死溶栓临床试验(TIMI)血流分级分为自发再通组(TIMI血流分级2~3级,n=43)和非自发再通组(TIMI血流分级0~1级,n=112),分析两组患者基线特征、MHR、临床生化指标及CAG特点的差异。应用多因素logistic回归分析IRA自发再通的影响因素,采用ROC曲线评估MHR对IRA自发再通的预测价值。结果:非自发再通组MHR水平明显高于自发再通组(P<0.001)。Logistic回归分析显示MHR是IRA自发再通的独立预测因子(OR=0.832,95%CI=0.764~0.905)。MHR预测IRA自发再通的ROC曲线下面积为0.821(95%CI=0.754~0.887); 界点是18.23,此时敏感度为83.7%,特异度为67.0%。结论:MHR可能与STEMI患者IRA自发再通独立相关,并对自发再通有一定的预测价值。
Abstract:
Aim:To evaluate the association of monocyte to high density lipoprotein cholesterol ratio(MHR)and spontaneous recanalization of infarct-related arteries(IRA)in patients with ST segment elevation acute myocardial infarction(STEMI).Methods:A total of 155 patients with STEMI treated with emergent coronary angiography(CAG)were enrolled.According to the thrombolysis in myocardial infarction(TIMI)flow grade,they were allocated into spontaneous recanalization group(SR group,TIMI grade 2 to 3, n=43)and non-spontaneous recanalization group(non-SR group,TIMI grade 0 to 1, n=112)and baseline characteristics, MHR, clinical biochemical parameters and results of CAG between the two groups were compared. Logistic regression was applied to evaluate the effect of different factors on the spontaneous recanalization. ROC curve was used to determine the prediction of MHR for spontaneous recanalization.Results: MHR was significantly higher in the non-SR group than that in the SR group(P<0.05).Logistic regression analysis showed that MHR was an independent predictor of spontaneous recanalization of IRA(OR=0.832, 95%CI=0.764-0.905). The area under the ROC curve of MHR predicting spontaneous recanalization of IRA was 0.821(95%CI=0.754-0.887).When the cut-off point was 18.23, the sensitivity was 83.7% and the specificity was 67.0%.Conclusion: MHR may be independently associated with spontaneous recanalization of infarct-related arteries in patients with STEMI, and has a certain predictive value for spontaneous recanalization.

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备注/Memo

备注/Memo:
【基金项目】河南省科技厅科技攻关计划项目(162102310516) 【作者简介】汤建民,通信作者,男,1970年11月生,博士,教授,主任医师,研究方向:冠心病介入治疗,E-mail:tjmgrx@163.com
更新日期/Last Update: 2019-01-20