[1]韩月霞),杨海军),李吉林),等.早期与中晚期贲门腺癌患者术后预后影响因素[J].郑州大学学报(医学版),2019,(02):179-182.[doi:10.13705/j.issn.1671-6825.2018.12.080]
 HAN Yuexia),YANG Haijun),LI Jilin),et al.Influencing factors of postoperation prognosis of early and advanced gastric cardiac adenocarcinoma patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(02):179-182.[doi:10.13705/j.issn.1671-6825.2018.12.080]
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早期与中晚期贲门腺癌患者术后预后影响因素()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年02期
页码:
179-182
栏目:
食管癌研究
出版日期:
2019-03-20

文章信息/Info

Title:
Influencing factors of postoperation prognosis of early and advanced gastric cardiac adenocarcinoma patients
作者:
韩月霞1)杨海军2)李吉林3)李欣然1)周福有4) 鲍启德5) 樊冰雨1) 程 锟16) 韩雪娜1) 王 苒 1) 宋 昕1)赵学科1)王立东1)
1)郑州大学第一附属医院河南省食管癌重点开放实验室; 省部共建食管癌防治国家重点实验室 郑州 450052 2)安阳肿瘤医院病理科 河南安阳 455000 3)林州市食管癌医院病理科 河南林州 456592 4)安阳市肿瘤医院胸外科 河南安阳455000 5)安阳市地区医院肿瘤科 河南安阳455000 6)郑州大学基础医学院病理学与病理生理学教研室 郑州450001
Author(s):
HAN Yuexia1)YANG Haijun2) LI Jilin3)LI Xinran1) ZHOU Fuyou4) BAO Qide5)FAN Bingyu1) CHENG Kun16) HAN Xuena1) WANG Ran1) SONG Xin1) ZHAO Xueke1) WANG Lidong1)
1)Henan Key Laboratory of Esophageal Cancer Research,the First Affiliated Hospital,Zhengzhou University; State Key Laboratory of Esophageal Cancer Prevention and Treatment,Zhengzhou 450052 2)Department of Pathology,Anyang Tumor Hospital,Anyang,Henan 455000 3)Department of Pathology,Linzhou Esophageal Cancer Hospital,Linzhou,Henan 456592 4)Department of Thoracic Surgery,Anyang Tumor Hospital,Anyang,Henan 455000 5)Department of Oncology,Anyang Regional Hospital,Anyang,Henan 455000 6)Department of Pathology and Pathophysiology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001
关键词:
贲门癌 术后预后 影响因素
Keywords:
gastric cardia adenocarcinoma postoperation prognosis influencing factor
分类号:
R735.2
DOI:
10.13705/j.issn.1671-6825.2018.12.080
摘要:
目的:探讨早期与中晚期贲门腺癌(GCA)患者的术后预后影响因素。方法:从河南省食管癌重点开放实验室50万例食管癌和贲门癌临床信息数据库中收集5 596例GCA患者的资料。其中男4 321例,女1 275例; 早、中、晚期患者分别有335、5 168和93例。患者均接受根治术治疗。结果:Cox分析结果显示,确诊年龄≥60岁(HR=3.069,95%CI=1.167~5.625)、有癌栓(HR=3.137,95%CI=1.063~9.253)是早期GCA患者术后预后的危险因素; 男性(HR=1.090,95%CI=1.002~1.185)、确诊年龄≥60岁(HR=1.409,95%CI=1.312~1.531)、有癌栓(HR=1.299,95%CI=1.167~1.446)、溃疡浸润型(HR=1.260,95%CI=1.108~1.432)、中低分化(HR=1.167,95%CI=1.103~1.344)、浸润程度深(HR=1.502,95%CI=1.350~1.671)是中晚期GCA患者术后预后的危险因素。结论:确诊年龄≥60岁、有癌栓是所有病期GCA患者术后预后的独立危险因素,而男性、浸润溃疡型、低分化、浸润程度深是中晚期患者术后预后的独立危险因素。
Abstract:
Aim:To investigate the influencing factors of postoperation prognosis of early and advanced gastric cardiac adenocarcinoma(GCA)patients.Methods:The data of 5 596 patients with GCA from the clinical information database of 500 000 cases of esophageal and gastric cardia carcinoma of Henan key laboratory of esophageal cancer research were collected.Among them, 4 321 cases were male, 1 275 cases were female; 335 patients were early stage, 5 168 patients were advanced stage and 93 patients were terminal stage. All the patients were treated with radical resection.Results:The Cox results showed age at diagnosis≥60 years(HR=3.069,95%CI=1.167-5.625), and cancer thrombosis(HR=3.137,95%CI=1.063-9.253)were independent influencing factors for prognosis of early GCA patients; male(HR=1.090,95%CI=1.002-1.185),age at diagnosis≥60 years(HR=1.409,95%CI=1.312-1.531), cancer thrombosis(HR=1.299,95%CI=1.167-1.446), invasive ulcer type(HR=1.260,95%CI=1.108-1.432), median or low differentiation degree(HR=1.167,95%CI=1.103-1.344),deep infiltration degree(HR=1.502,95%CI=1.350-1.167)were independent influencing factors for prognosis of patients with advanced GCA.Conclusion:Age at diagnosis≥60 years and cancer thrombosis are independent risk factors for GCA prognosis; male, invasive ulcer type, poor differentiation and deep infiltration degree are only independent risk factors for the patients with advanced GCA.

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金项目(81872032,U1804262,81472323)
【作者简介】王立东,通信作者,男,1958年8月生,博士,教授,研究方向:食管、贲门癌变机制及防治,E-mail:ldwang2007@126.com
更新日期/Last Update: 2019-03-20