[1]千新玲),刘晓田),屠润琪),等.ZFAND3基因rs9470794多态性与河南汉族农村人群2型糖尿病易感性的关系[J].郑州大学学报(医学版),2019,(02):199-203.[doi:10.13705/j.issn.1671-6825.2018.09.132]
 QIAN Xinling),LIU Xiaotian),TU Runqi),et al.Association of ZFAND3 gene rs9470794 polymorphism with the risk of type 2 diabetes mellitus in a rural Han population in Henan Province[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(02):199-203.[doi:10.13705/j.issn.1671-6825.2018.09.132]
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ZFAND3基因rs9470794多态性与河南汉族农村人群2型糖尿病易感性的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年02期
页码:
199-203
栏目:
论著
出版日期:
2019-03-20

文章信息/Info

Title:
Association of ZFAND3 gene rs9470794 polymorphism with the risk of type 2 diabetes mellitus in a rural Han population in Henan Province
作者:
千新玲1)刘晓田1)屠润琪1) 张海庆1)田忠艳1) 张 霞1)李瑞颖1)毛振兴1)王重建1)李玉倩2)
1)郑州大学公共卫生学院流行病学教研室 郑州450001 2)郑州大学药学院临床药理学系 郑州 450001
Author(s):
QIAN Xinling1) LIU Xiaotian1) TU Runqi1) ZHANG Haiqing1) TIAN Zhongyan1) ZHANG Xia1) LI Ruiying1) MAO Zhenxing1) WANG Chongjian1) LI Yuqian2)
1)Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001 2)Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001
关键词:
2型糖尿病 ZFAND3基因 基因多态性 交互作用 河南省 汉族
Keywords:
type 2 diabetes mellitus ZFAND3 gene gene polymorphism interaction Henan Province Han population
分类号:
R181.2
DOI:
10.13705/j.issn.1671-6825.2018.09.132
摘要:
目的:探讨ZFAND3基因rs9470794多态性与河南农村汉族人群2型糖尿病易感性的关系。方法:采用1:1匹配病例对照设计,从河南农村队列研究中分别抽取526对2型糖尿病患者和对照,采用SNPscanTM高通量SNP分型技术进行基因分型; 应用条件logistic回归模型分析rs9470794位点多态性与2型糖尿病易感性的关系。应用logistic回归和非线性混合效应模型探讨基因-环境交互作用。结果:病例组和对照组rs9470794基因型分布频率差异有统计学意义(P=0.026); 调整混杂因素后,突变纯合子(CC)携带者发生2型糖尿病的风险是非携带者的1.750倍(95%CI=1.075~2.848)。交互作用分析显示,rs9470794基因型与BMI对2型糖尿病的发生存在相乘交互作用(OR=1.304, 95%CI=1.199~1.419)。结论:ZFAND3基因rs9470794多态性与2型糖尿病易感性有关,且该位点多态性与BMI对2型糖尿病的发生存在相乘交互作用。
Abstract:
Aim:To explore the association of zinc finger AN1-type containing 3(ZFAND3)gene rs9470794 polymorphism with the risk of type 2 diabetes mellitus(T2DM)in a rural Han population in Henan.Methods:Based on the 1:1 matched case-control design, a total of 526 pairs of patients with T2DM and controls were collected from the Henan Rural Cohort Study. The SNPscanTM Kit was used to detect the genotypes. Conditional logistic regression was used to evaluate the association of rs9470794 with the risk of T2DM. Logistic regression and nonlinear mixed effect model were used to estimate the gene-environment interactions.Results:The distribution of rs9470794 genotypes frequency had significant difference between the two groups(P=0.026). Compared with non-carriers, the carriers of mutation homozygote(CC)were 1.750 times more likely to develop T2DM after adjusting confounding factors(OR=1.750,95%CI=1.075-2.848). The multiplicative interaction between rs9470794 polymorphism and BMI was detected(OR=1.304, 95%CI=1.199-1.419).Conclusion:ZFAND3 gene rs9470794 polymorphism is associated with T2DM, and there is multiplicative interaction between rs9470794 and BMI in the risk of T2DM.

参考文献/References:

[1] LIU XT,LI YQ,LI LL,et al.Prevalence, awareness, treatment, control of type 2 diabetes mellitus and risk factors in Chinese rural population: the RuralDiab study[J].Sci Rep,2016,6:31426
[2] 高莉,周刚,冯石献,等.河南省居民糖尿病流行特征调查[J].郑州大学学报(医学版),2014,49(1):123
[3] YANG WY,LU JM,WENG JP,et al.Prevalence of Diabetes among Men and Women in China[J].N Engl J Med,2010,362(12):1090
[4] 杨凯丽,霍文倩,刘晓田,等.河南农村人群KCNQ1基因rs2299620位点多态性与2型糖尿病的关系[J].郑州大学学报(医学版),2018,53(4):421
[5] ARORA GP,ALMGREN P, BRØNS C,et al.Association between genetic risk variants and glucose intolerance during pregnancy in North Indian women[J].BMC Med Genomics,2018,11:64
[6] CHO YS,CHEN CH,HU C,et al.Meta-analysis of genome-wide association studies identifies 8 new loci for type 2 diabetes in East Asians[J].Nat Genet,2011,44(1):67
[7] SAKAI K,IMAMURA M,TANAKA Y,et al.Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population[J].PLoS One,2013,8(9):e76317
[8] MULLER YL,PIAGGI P,CHEN P,et al.Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians:suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3[J].Diabetes Metab Res Rev,2017,33(4):e2869
[9] LI GR,WAKIL SM,MEYER BF,et al.Replication of type 2 diabetes-associated variants in a Saudi Arabian population[J].Physiol Genomics,2018,50(4):296
[10]American Diabetes Association. Clinical Practice Recommendations 2005[J]. Diabetes Care,2005,28(suppl1):s1
[11]杨月欣,张环美.《中国居民膳食指南(2016)》简介[J].营养学报,2016,38(3):209
[12]CRAIG CL,MARSHALL AL,SJÖSTRÖM M,et al.International physical activity questionnaire: 12-country reliability and validity[J].Med Sci Sports Exerc,2003,35(8):1381
[13]中国肥胖问题工作组.中国成人超重和肥胖症预防与控制指南(节录)[J].营养学报,2004,26(1):1
[14]袁悦,李楠,任爱国,等.流行病学研究中相加和相乘尺度交互作用的分析[J].现代预防医学,2015,42(6):961
[15]DE LUIS O,LÓPEZ-FERNÁNDEZ LA,DEL MAZO J.Tex27,a gene containing a zinc-finger domain,is up-regulated during the haploid stages of spermatogenesis[J].Exp Cell Res,1999,249(2):320
[16]OTAKE S,ENDO D,PARK MK.Molecular characterization of two isoforms of ZFAND3 cDNA from the Japanese quail and the leopard gecko,and different expression patterns between testis and ovary[J].Gene,2011,488(1/2):23

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金资助项目(81602925, 81573243); 国家重点研发计划“精准医学研究”重点专项(2016YFC0900803)
【作者简介】李玉倩,通信作者,女,1977年2月生,硕士,讲师,研究方向:临床药理学,E-mail: liyuqian@zzu.edu.cn
更新日期/Last Update: 2019-03-20