[1]王海旭),刘献志),杨 波),等.脑胶质母细胞瘤切除术中脑室开放的影响因素及预后分析[J].郑州大学学报(医学版),2019,(02):283-287.[doi:10.13705/j.issn.1671-6825.2018.08.139]
 WANG Haixu),LIU Xianzhi),YANG Bo),et al.Analysis of related factors of ventricular opening in glioblastoma and its influence on prognosis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(02):283-287.[doi:10.13705/j.issn.1671-6825.2018.08.139]
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脑胶质母细胞瘤切除术中脑室开放的影响因素及预后分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年02期
页码:
283-287
栏目:
应用研究
出版日期:
2019-03-20

文章信息/Info

Title:
Analysis of related factors of ventricular opening in glioblastoma and its influence on prognosis
作者:
王海旭1)刘献志2)杨 波2)吴力新2)田 毅2)孙同文1)万有栋3)宋来君2)
1)郑州大学第一附属医院综合ICU 郑州 450052 2)郑州大学第一附属医院神经外科 郑州 450052 3)青岛大学附属医院EICU 山东青岛 266071
Author(s):
WANG Haixu1)LIU Xianzhi2)YANG Bo2)WU Lixin2)TIAN Yi2)SUN Tongwen1)WAN Youdong3)SONG Laijun2)
1)GICU, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Department of Neurosurgery, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 3)EICU, the Affiliated Hospital, Qingdao University, Qingdao, Shandong 266071
关键词:
脑室开放 胶质母细胞瘤
Keywords:
ventricle opening glioblastoma
分类号:
R739.41
DOI:
10.13705/j.issn.1671-6825.2018.08.139
摘要:
目的:探讨人脑胶质母细胞瘤(GBM)切除术中脑室开放的相关因素及其对预后的影响。方法:收集519例接受原发性GBM切除的患者资料,按术中是否进行脑室开放进行分组,回顾性分析与脑室开放相关因素,用Kaplan-Meier生存曲线法估计两组的生存率,并用log-rank检验进行生存率的比较。利用Cox比例风险回归模型对其他相关因素进行校正,评价脑室开放对手术预后的影响。结果:519例患者中212例术中开放了脑室。多因素logistic回归分析结果显示,次全切除和脑室粘连的患者更倾向于术中开放脑室(P<0.05)。生存分析显示,两组的中位生存期分别为12.1和15.7个月,差异无统计学意义(P=0.152)。结论:GBM切除术中脑室开放是安全的。
Abstract:
Aim:To analysis the related factors of ventricular opening in glioblastoma(GBM)and its influence on prognosis.Methods:A total of 519 patients who underwent primary GBM resection were collected and grouped according to whether the ventricle was open or not during surgery. Retrospective analysis of individual and clinical factors associated with ventricular openness was made. The Kaplan-Meier survival curve was used to estimate the survival rate of the two groups, and the survival rate was compared by log-rank test. The Cox proportional hazards regression model was used to correct other relevant factors in evaluating the impact of ventricular opening on surgical outcomes.Results:Among 519 patients,212 underwent intraoperative ventricular opening. Multivariate logistic regression showed that patients with subtotal resection and ventricular adhesion were more likely to have open ventricles(P<0.05). The medium survival of the two groups was 12.1 and 15.7 months(P=0.152).Conclusion:Ventricular opening is considerable safe during GBM resection.

参考文献/References:

[1] STUPP R,MASON WP,VAN DEN BENT MJ,et al.Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma[J].N Engl J Med,2005,352(10):987
[2] ELLIOTT JP,KELES GE,WAITE M,et al.Ventricular entry during resection of malignant gliomas:effect on intracranial cerebrospinal fluid tumor dissemination[J].J Neurosurg,1994,80(5):834
[3] ADEBERG S,KÖNIG L,BOSTEL T,et al.Glioblastoma recurrence patterns after radiation therapy with regard to the subventricular zone[J].Int J Radiat Oncol Biol Phys,2014,90(4):886
[4] FISCHER CM,NEIDERT MC,PÉUS D,et al.Hydrocephalus after resection and adjuvant radiochemotherapy in patients with glioblastoma[J].Clin Neurol Neurosurg,2014,120:27
[5] JOHN JK,ROBIN AM,PABANEY AH,et al.Complications of ventricular entry during craniotomy for brain tumor resection[J].J Neurosurg,2017,127(2):426
[6] MARQUARDT G,SETZER M,LANG J,et al.Delayed hydrocephalus after resection of supratentorial malignant gliomas[J].Acta Neurochir(Wien),2002,144(3):227
[7] BULSTRODE HJ,NATALWALA A,GRUNDY PL.Atypical presentation of delayed communicating hydrocephalus after supratentorial glioma resection with opening of the ventricles[J].Br J Neurosurg,2012,26(2):222
[8] CASTRO BA,IMBER BS,CHEN RA,et al.Ventriculoperitoneal shunting for glioblastoma: risk factors, indications, and efficacy[J].Neurosurgery,2017,80(3):421
[9] LI YM,SUKI D,HESS K,et al.The influence of maximum safe resection of glioblastoma on survival in 1229 patients: can we do better than gross-total resection?[J].J Neurosurg,2016,124(4):977
[10]WANGARYATTAWANICH P,HATAMI M,WANG JA,et al.Multicenter imaging outcomes study of the cancer genome atlas glioblastoma patient cohort: imaging predictors of overall and progression-free survival[J].Neuro Oncol,2015,17(11):1525
[11]MONTANO N,D'ALESSANDRIS QG,BIANCHI F,et al.Communicating hydrocephalus following surgery and adjuvant radiochemotherapy for glioblastoma clinical article[J].J Neurosurg,2011,115(6):1126
[12]ONDA K,TANAKA R,TAKAHASHI H,et al.Symptomatic cerebrospinal fluid dissemination of cerebral glioblastoma:computed tomographic findings in 11 cases[J].Neuroradiology,1990,32(2):146
[13]ANDO S,MORITAKE K.Pure optic ataxia associated with a right parieto-occipital tumour[J].J Neurol Neurosurg Psychiatry,1990,53(9):805
[14]PERRINI P,SCOLLATO A,CIOFFI F,et al.Radiation leukoencephalopathy associated with moderate hydrocephalus: intracranial pressure monitoring and results of ventriculoperitoneal shunting[J].Neurol Sci,2002,23(5):237

备注/Memo

备注/Memo:
【基金项目】河南省卫生计生科技创新型人才“51282”工程项目(豫卫科[2016]32号)
【作者简介】宋来君,通信作者,男,1952年9月生,本科,教授,主任医师,研究方向:颅内肿瘤的基础与临床,E-mail:laijunsong@126.com
更新日期/Last Update: 2019-03-20