[1]石森林,吕爱香,宋文妍,等.胚胎发育动力学参数与胚胎种植率的关系[J].郑州大学学报(医学版),2019,(04):563-567.[doi:10.13705/j.issn.1671-6825.2018.10.113]
 SHI Senlin,LYU Aixiang,SONG Wenyan,et al.Relationship between embryo dynamic parameters and embryo implantation rate[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(04):563-567.[doi:10.13705/j.issn.1671-6825.2018.10.113]
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胚胎发育动力学参数与胚胎种植率的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年04期
页码:
563-567
栏目:
应用研究
出版日期:
2019-07-20

文章信息/Info

Title:
Relationship between embryo dynamic parameters and embryo implantation rate
作者:
石森林吕爱香宋文妍金海霞
郑州大学第一附属医院生殖医学中心 郑州 450052
Author(s):
SHI SenlinLYU AixiangSONG WenyanJIN Haixia
Center of Reproductive Medicine,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
胚胎动力学 胚胎种植 体外受精
Keywords:
embryo dynamics embryo implantation in vitro fertilization
分类号:
R715.5
DOI:
10.13705/j.issn.1671-6825.2018.10.113
摘要:
目的:探讨胚胎发育动力学参数与胚胎种植率之间的关系,旨在为选择种植率更高的胚胎提供依据。方法:回顾性分析利用EmbryoScope Timelapse胚胎培养系统进行培养和监测的316个常规体外受精周期,其中种植率为0%者(未种植组)146例,种植率为100%者(种植组)170例,对两组共601枚胚胎进行动力学分析,比较两组胚胎动力学参数的差异。用四分位分析法对胚胎发育的每个时间段进行分析,找出种植率最高的优势时间段。结果:种植组胚胎授精至原核出现时间(tPNa)、授精至原核消失时间(tPNf)、授精至二细胞时间(t2)、授精至三细胞时间(t3)、授精至四细胞时间(t4)、授精至六细胞时间(t6)、授精至七细胞时间(t7)、授精至八细胞时间(t8)、s2(t4-t3)均短于未种植组(P<0.05)。1.94 h≤tPNa<7.73 h、15.53 h≤tPNf<21.08 h、17.87 h≤t2<23.59 h、22.15 h≤t3<36.52 h、25.87 h≤t4<37.63 h、31.52 h≤授精至五细胞时间(t5)<53.66 h、32.58 h≤t6<55.37 h、33.58 h≤t7<57.20 h、40.88 h≤t8<59.71 h、0.18 h≤s2<1.23 h更有利于胚胎种植,其中15.53 h≤tPNf<21.08 h和17.87 h≤t2<23.59 h种植率均高于其他3个时间段(P<0.001)。结论:胚胎发育进程快的胚胎种植率高; 15.53 h≤tPNf<21.08 h、17.87 h≤t2<23.59 h有利于胚胎种植。
Abstract:
Aim:To study relationship between embryo dynamic parameters and embryo implantation rate for the selection of embryos for transfer in clinical practice.Methods:A total of 601 embryos of 316 in vitro fertilization cycles(146 cycles were 0% implantation and 170 cycles were 100% implantation)cultured in an incubator with EmbryoScope Timelapse system were retrospectively analysed. The time period of embryo development was analyzed with the method of quartile analysis to find the dominant time period with the highest planting rate.Results:Insemination to pronucleus appearance time(tPNa), insemination to pronucleus disappearance time(tPNf), insemination to two cells time(t2), insemination to three cells time(t3), insemination to four cells time(t4), insemination to six cells time(t6), insemination to seven cells time(t7), insemination to eight cells time(t8), and s2(t4-t3)of planting group were significantly lower than those of non-planting group(P<0.05).1.94 hours≤tPNa<7.73 hours,15.53 hours≤tPNf<21.08 hours,17.87 hours≤t2<23.59 hours,22.15 hours≤t3<36.52 hours,25.87 hours≤t4<37.63 hours, 31.52 hours≤insemination to five cells time(t5)<53.66 hours,32.58 hours≤t6<55.37 hours,33.58 hours≤t7<57.20 hours,40.88 hours≤t8<59.71 hours,0.18 hours≤s2<1.23 hours had better implantation rate.When 15.53 hours≤tPNf<21.08 hours,17.87 hours≤t2<23.59 hours,the planting rates were significantly higher than those of the other three periods(P<0.001).Conclusion:Embryos with rapid development have higher implantation rate.The most predictive parameters for implantation are 15.53 hours≤tPNf<21.08 hours and 17.87 hours≤t2<23.59 hours.

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金资助项目(81701527); 河南省高等学校重点科研计划项目(17A320052)
【作者简介】金海霞,通信作者,女,1975年3月生,博士,副教授,研究方向:生殖医学胚胎发育,E-mail:jhxgl@126.com
更新日期/Last Update: 2019-07-20