[1]施梦丽,杨 萍,杨 洋,等.血清TAM联合TPSA、FPSA/TPSA对前列腺癌的诊断价值[J].郑州大学学报(医学版),2019,(04):597-599.[doi:10.13705/j.issn.1671-6825.2018.11.135]
 SHI Mengli,YANG Ping,YANG Yang,et al.Diagnostic value of serum TAM combined with TPSA and FPSA/TPSA for prostate cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(04):597-599.[doi:10.13705/j.issn.1671-6825.2018.11.135]
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血清TAM联合TPSA、FPSA/TPSA对前列腺癌的诊断价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年04期
页码:
597-599
栏目:
应用研究
出版日期:
2019-07-20

文章信息/Info

Title:
Diagnostic value of serum TAM combined with TPSA and FPSA/TPSA for prostate cancer
作者:
施梦丽杨 萍杨 洋孙永敏吕春歌李 晶曹秋影
郑州大学第二附属医院核医学科 郑州 450014
Author(s):
SHI MengliYANG PingYANG YangSUN YongminLYU ChungeLI JingCAO Qiuying
Department of Nuclear Medicine,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014
关键词:
前列腺癌 肿瘤相关物质 前列腺特异性抗原
Keywords:
prostatic cancer tumor associated material prostate specific antigen
分类号:
R446.11
DOI:
10.13705/j.issn.1671-6825.2018.11.135
摘要:
目的:探讨血清肿瘤相关物质(TAM)联合TPSA、FPSA/TPSA对前列腺癌的诊断价值。方法:研究对象分为3组,前列腺癌组50例、良性前列腺增生组(BPH组)58例、正常对照组67例。采集空腹静脉血,测定血清中TAM、TPSA、FPSA的含量并计算FPSA/TPSA的比值。结果:前列腺癌组TPSA、FPSA、TAM均高于BPH组及正常对照组,FPSA/TPSA则低于BPH组及正常对照组; BPH组TPSA、FPSA均高于正常对照组(P<0.05)。以血清TPSA>4.0 μg/L, FPSA/TPSA<0.16,TAM>95 U/mL为临界值时,TPSA、FPSA/TPSA、TAM、TAM+TPSA、TAM+ FPSA/TPSA诊断前列腺癌的灵敏度和特异度分别为(92.0%、69.6%),(80.0%、80.8%),(84.0%、82.4%),(96.0%、88.0%),(94.0%、86.4%),且血清TAM联合TPSA诊断前列腺癌的灵敏度和特异度更高。结论:血清TAM联合TPSA可提高对前列腺癌的诊断效能。
Abstract:
Aim:To probe into the diagnostic value of serum tumor associated material(TAM)combined with TPSA and FPSA/TPSA test for prostate cancer.Methods:The subjects were allocated into three groups,50 patients with prostate cancer(PCa group), 58 patients with benign prostatic hyperplasia(BPH), and 67 normal controls.Fasting venous blood was taken, the contents of TAM, TPSA, and FPSA in serum were measured,and the value of FPSA/TPSA was calculated.Results:TPSA, FPSA, and TAM in the PCa group were higher than those in the BPH group and the normal control group,while FPSA/TPSA in the PCa group was lower(P<0.05). TPSA and FPSA in the BPH group were both higher than those in the normal control group(P<0.05).With serum TPSA>4.0 μg/L, FPSA/TPSA<0.16, TAM>95 U/mL as the critical value, the sensitivity and specificity of TPSA, FPSA/TPSA, TAM,TAM+TPSA, TAM+FPSA/TPSA in the diagnosis of prostate cancer were(92.0%, 69.6%),(80.0%, 80.8%),(84.0%, 82.4%),(96.0%, 88.0%),(94.0%, 86.4%), respectively.The diagnostic efficacy of TAM+TPSA was better than TPSA.Conclusion:Serum TAM combined with TPSA can improve the diagnostic efficacy of prostate cancer.

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备注/Memo

备注/Memo:
【基金项目】河南省医学科技攻关计划项目(201503092)
【作者简介】杨萍,通信作者,女,1962年11月生,本科,主任医师,研究方向:核素体外分析、核素显像诊断与核素治疗,E-mail:446868104@qq.com
更新日期/Last Update: 2019-07-20