[1]秦 原,黄小力,杨禄红.曲普瑞林治疗特发性中枢性性早熟女童的疗效[J].郑州大学学报(医学版),2019,(04):599-603.[doi:10.13705/j.issn.1671-6825.2019.03.029]
 QIN Yuan,HUANG Xiaoli,YANG Luhong.Therapeutic effects of triptorelin in girls with idiopathic central precocious puberty[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(04):599-603.[doi:10.13705/j.issn.1671-6825.2019.03.029]
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曲普瑞林治疗特发性中枢性性早熟女童的疗效()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年04期
页码:
599-603
栏目:
应用研究
出版日期:
2019-07-20

文章信息/Info

Title:
Therapeutic effects of triptorelin in girls with idiopathic central precocious puberty
作者:
秦 原黄小力杨禄红
华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)小儿内分泌遗传代谢科 武汉 430016
Author(s):
QIN Yuan HUANG XiaoliYANG Luhong
Department of Endocrinology, Genetics and Metabolism in Children, the Affiliated Wuhan Children's Hospital(Wuhan Maternal and Child Health Hospital),Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430016
关键词:
特发性中枢性性早熟 曲普瑞林 IGF-1 Ghrelin 性激素
Keywords:
idiopathic central precocious puberty triptorelin IGF-1 Ghrelin sex hormone
分类号:
R725.8
DOI:
10.13705/j.issn.1671-6825.2019.03.029
摘要:
目的:探讨曲普瑞林治疗特发性中枢性性早熟(ICPP)女童的效果。方法:选取60例ICPP女童,均予以曲普瑞林注射治疗。测定患儿治疗前、治疗6个月后身高、体重、骨龄(BA)、骨龄差值/年龄差值(ΔBA/ΔCA)、预测成年终身高(PAH)等生长发育相关指标,比较治疗前后血清胰岛素样生长因子1(IGF-1)、生长激素释放肽(Ghrelin)及性激素[雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)]水平,观察治疗前后子宫体积、卵巢体积的变化,记录不良反应发生情况。结果:经过6个月的治疗,与治疗前比较,患儿身高、PAH、体重、BA均增加,ΔBA/ΔCA降低(P<0.05); 血清IGF-1水平降低,血清Ghrelin、E2水平及FSH、LH基础值和峰值均降低,子宫体积和卵巢体积减小(P<0.05); 总不良反应发生率为5.00%(3/60),未见严重不良反应。结论:曲普瑞林治疗ICPP女童有效,安全性较高。
Abstract:
Aim:To explore the therapeutic effects of triptorelin in girls with idiopathic central precocious puberty(ICPP).Methods:A total of 60 ICPP girls were selected for the study, and they were treated with triptorelin acetate injection. The related indexes of growth and development such as height, body weight, bone age(BA), bone age difference/age difference(ΔBA/ΔCA)and predicted adult lifelong height(PAH)were observed and calculated before and after treatment. The levels of serum insulin-like growth factor 1(IGF-1), Ghrelin and sex hormones[estradiol(E2), follicle stimulating hormone(FSH), luteinizing hormone(LH)] were compared before and after treatment. The changes of uterine volume and ovarian volume were observed before and after treatment, and the occurrence of adverse reactions was recorded.Results:After 6 months of treatment, the height and PAH were elevated,body weight and BA were increased,while ΔBA/ΔCA was decreased compared with those before treatment(P<0.05). The level of serum IGF-1 was decreased compared with that before treatment, the levels of serum Ghrelin,E2,basal value and peak value of FSH and LH were lower, and the uterine volume and ovarian volume were significantly smaller than those before treatment(P<0.05). The total incidence rate of adverse reactions was 5.00%(3/60), and there was no serious adverse reactions.Conclusion:Triptorelin has high efficacy in the treatment of ICPP girls without significant adverse reactions.

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备注/Memo

备注/Memo:
【基金项目】湖北省自然科学基金资助面上项目(2015CKC909)
【作者简介】秦原,通信作者,女,1978年3月生,硕士,主治医师,研究方向:小儿内分泌疾病,E-mail:qinyuan20170101@163.com; 黄小力,通信
作者,男,1963年4月生,本科,主任医师,研究方向:小儿内分泌疾病,E-mail:huangxl2011@163.com
更新日期/Last Update: 2019-07-20