[1]李宗明,焦德超,韩新巍,等.125I粒子双链放疗引流管在恶性阻塞性黄疸治疗中的初步应用[J].郑州大学学报(医学版),2019,(05):646-649.[doi:10.13705/j.issn.1671-6825.2019.06.100]
 LI Zongming,JIAO Dechao,HAN Xinwei,et al.Application of biliary drainage tube loaded double 125I seeds strands in treatment of malignant biliary obstruction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(05):646-649.[doi:10.13705/j.issn.1671-6825.2019.06.100]
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125I粒子双链放疗引流管在恶性阻塞性黄疸治疗中的初步应用()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年05期
页码:
646-649
栏目:
系列研究
出版日期:
2019-09-20

文章信息/Info

Title:
Application of biliary drainage tube loaded double 125I seeds strands in treatment of malignant biliary obstruction
作者:
李宗明焦德超韩新巍雷钦宇周学良杨 红徐 苗
郑州大学第一附属医院放射介入科 郑州 450052
Author(s):
LI ZongmingJIAO Dechao HAN Xinwei LEI Qinyu ZHOU Xueliang YANG Hong XU Miao
Department of Interventional Radiology, the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
125I 近距离放疗 阻塞性黄疸 胆道引流管 胆道支架
Keywords:
125I close range radiotherapy obstructive jaundice biliary drainage tube biliary stent
分类号:
R575
DOI:
10.13705/j.issn.1671-6825.2019.06.100
摘要:
目的:评估125I粒子双链放疗引流管应用于恶性阻塞性黄疸的有效性和安全性。方法:42例恶性阻塞性黄疸患者,22例(A组)接受镍钛合金胆道支架+普通胆道引流管置入术,20例(B组)接受镍钛合金胆道支架+自制125I双链放疗引流管置入术。记录术前和术后1个月总胆红素(TBIL)、直接胆红素(DBIL)、白细胞计数。记录术前和术后3个月肿瘤直径,计算术前术后差值。记录支架通畅时间、生存时间和并发症发生情况。结果:两组术前术后TBIL、DBIL、白细胞计数差值差异均无统计学意义(P>0.05)。术后3个月A组肿瘤增大,B组肿瘤缩小,两组术前术后肿瘤直径差值差异有统计学意义(P<0.05)。A、B组支架通畅时间分别为(3.55±0.76)个月和(8.76±1.85)个月,生存时间分别为(133.5±27.8)d和(252.5±114.5)d,差异均具有统计学意义(P<0.05); 两组均未发生致命性手术并发症,轻微并发症发生率差异无统计学意义(P>0.05)。结论:125I粒子双链放疗引流管可以安全有效的控制肿瘤、延长胆道支架通畅时间,延长恶性阻塞性黄疸患者的生存时间。
Abstract:
Aim:To evaluate the efficacy and safety of biliary stent combined with drainage tube loaded double 125I seeds strands in treating malignant biliary obstruction(MBO).Methods:The data of 42 MBO patients were retrospectively analyzed. Twenty -two patients(group A )were implanted metal stent and ordinary biliary drainage tube, while the other 20 patients(group B)were inserted metal stent and biliary drainage tube loaded double 125I seeds strands. The level of bilirubin(TBIL and DBIL)and white blood cell count(WBC)before and 1 month after the procedure,the diameter of neoplasm before and 3 months after the procedure as well as stent patency time, survival time and complications over follow-up period were evaluated.Results:There was no significant difference between the two groups in the changes of TBIL,DBIL and WBC(P>0.05). The tumor in group A increased and decreased in group B 3 months after operation,and the difference was statistically significant(P<0.05). The average time of stent patency in group A and group B was(3.55±0.76)months and(8.76±1.85)months,respectively, the average survival time was(133.5±27.8)days and(252.5±114.5)days, respectively, and the differences were statistically significant(P<0.05). There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion:Application of biliary drainage tube loaded double 125I seeds strands could limit tumor progression, improve stent patency time and overall survival in patients with MBO.

参考文献/References:

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备注/Memo

备注/Memo:
【基金项目】河南省科技攻关计划项目(172102310388)
【作者简介】韩新巍,通信作者,男,1958年6月生,博士,主任医师,研究方向:各类疾病的介入治疗,E-mail:hanxinwei2006@163.com
更新日期/Last Update: 2019-09-20