[1]刘曼曼),李 静),王金铭),等.高危型HPV阳性患者血清miRNA-26a表达水平对宫颈癌的预测价值[J].郑州大学学报(医学版),2019,(05):696-699.[doi:10.13705/j.issn.1671-6825.2019.01.076]
 GUAN Yichun),LIU Zhaozhao)LIU Manman),LI Jing),et al.Predictive value of serum miRNA-26a for high risk HPV positive cervical cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(05):696-699.[doi:10.13705/j.issn.1671-6825.2019.01.076]
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高危型HPV阳性患者血清miRNA-26a表达水平对宫颈癌的预测价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年05期
页码:
696-699
栏目:
应用研究
出版日期:
2019-09-20

文章信息/Info

Title:
Predictive value of serum miRNA-26a for high risk HPV positive cervical cancer
作者:
刘曼曼1)李 静2)王金铭2)张 展3)杜明泽1)王碧君1)管一春1)刘朝朝1)
11)郑州大学第三附属医院生殖中心 郑州 450052;2)郑州大学第三附属医院妇产科 郑州 450052;3)郑州大学第三附属医院检验科 郑州 450052
Author(s):
GUAN Yichun1) LIU Zhaozhao1)LIU Manman1) LI Jing2) WANG Jinming2) ZHANG Zhan3) DU Mingze1) WANG Bijun1)
1)Department of Reproduction Center,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;2)Department of Gynecology and Obstetrics,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;3)Department of Clinical Laboratory,the T
关键词:
宫颈癌 miRNA-26a 高危型人乳头瘤病毒
Keywords:
cervical cancer miRNA-26a high risk HPV
分类号:
R737.33
DOI:
10.13705/j.issn.1671-6825.2019.01.076
摘要:
目的:探讨高危型人乳头瘤病毒(HPV)阳性患者血清miRNA-26a(miR-26a)表达水平对宫颈癌的预测价值。方法:HPV16和(或)HPV18阳性的宫颈癌和良性病变患者各50例,采用实时荧光定量PCR检测患者血清和宫颈组织中miR-26a的表达水平。结果:宫颈癌患者血清和宫颈组织中miR-26a的表达水平均低于良性病变患者(P<0.05)。宫颈癌患者血清和宫颈组织中miR-26a的表达水平呈正相关(rP=0.535,P<0.001)。利用血清miR-26a表达水平鉴别诊断HPV16和(或)HPV18阳性的宫颈癌和良性病变患者,ROC曲线下面积为0.887( 95%CI=0.808~0.941),诊断界点取3.94时,敏感度为78.0%,特异度为88.0%。结论:血清miR-26a表达水平对高危型HPV阳性的宫颈癌具有一定的预测价值。
Abstract:
Aim:To clarify the predictive value of serum miRNA-26a(miR-26a)for high risk HPV positive cervical cancer.Methods:Fifty patients with cervical cancer and 50 patients with benign lesions, and all with positive HPV16 and/or HPV18, were subjected to detect the expression levels of miR-26a in serum and cervical tissue by real-time fluorescence quantitative PCR.Results:The expression levels of miR-26a in serum and cervical tissue of cervical cancer patients were both lower than those of benign lesions patients(P<0.05).The expression level of miR-26a in serum was positively related with that in cervical tissue in cervical cancer patients(rP=0.535, P<0.001). The area under ROC was 0.887(95%CI=0.808-0.941), and the sensitivity and specificity were 78.0% and 88.0, respectively when the diagnostic threshold was 3.94.Conclusion:The expression level of miR-26a in serum could be used to predict the cervical cancer in high risk HPV positive patients.

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备注/Memo

备注/Memo:
【基金项目】河南省科技攻关计划项目(182102310626)
【作者简介】刘曼曼,女,1985年4月生,硕士,主治医师,研究方向:妇产科学、生殖内分泌学,E-mail:huakailuolan@163.com
更新日期/Last Update: 2019-09-20