[1]朱 洁),高伟娜),刘 冲),等.妊娠期糖尿病孕妇产后糖代谢异常的危险因素和孕中期血清硒蛋白P的预测价值[J].郑州大学学报(医学版),2019,(05):750-753.[doi:10.13705/j.issn.1671-6825.2019.05.120]
 ZHU Jie),GAO Weina),LIU Chong),et al.Influencing factors of abnormal postpartum glucose metabolism in pregnant women with gestational diabetes mellitus and the predictive value of serum selenium protein P in mid-pregnancy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(05):750-753.[doi:10.13705/j.issn.1671-6825.2019.05.120]
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妊娠期糖尿病孕妇产后糖代谢异常的危险因素和孕中期血清硒蛋白P的预测价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年05期
页码:
750-753
栏目:
应用研究
出版日期:
2019-09-20

文章信息/Info

Title:
Influencing factors of abnormal postpartum glucose metabolism in pregnant women with gestational diabetes mellitus and the predictive value of serum selenium protein P in mid-pregnancy
作者:
朱 洁1)高伟娜1)刘 冲1)杨再刚2)
1)郑州大学第一附属医院产科 郑州 450052;2)郑州大学第一附属医院老年内分泌科 郑州 450052
Author(s):
ZHU Jie1) GAO Weina1) LIU Chong1) YANG Zaigang2)
1)Department of Obstetrics, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052; 2)Department of Geriatric Endocrinology, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
关键词:
硒蛋白P 妊娠期糖尿病 糖代谢异常
Keywords:
selenoprotein P gestational diabetes mellitus abnormal glucose metabolism
分类号:
R714
DOI:
10.13705/j.issn.1671-6825.2019.05.120
摘要:
目的:探讨妊娠期糖尿病(GDM)孕妇产后糖代谢异常的危险因素和孕中期血清硒蛋白P的预测价值。方法:回顾性分析GDM孕妇400例,根据产后1 a的75 g 葡萄糖耐量结果将其分成糖代谢正常组282例和糖代谢异常组118例。 比较两组患者基线资料和孕中期血清硒蛋白P水平,logistic回归分析GDM患者产后糖代谢异常的危险因素。结果:两组患者孕前BMI、有糖尿病家族史、孕期增重、甘油三酯(TG)、高密度脂蛋白、低密度脂蛋白和孕中期血清硒蛋白P水平等差异有统计学意义(P<0.05)。 Logistic回归分析显示孕前BMI>24 kg/m2(OR=1.408,95%CI=1.137~1.743)、有糖尿病家族史(OR=1.718,95%CI=1.443~2.045)、孕中期TG>1.02 mmol/L(OR=1.259,95%CI=1.182~1.340)和血清硒蛋白P>2.69 mmol/L(OR=2.010,95%CI=1.168~3.459)是GDM孕妇产后糖代谢异常的危险因素。孕中期血清硒蛋白P对GDM孕妇产后糖代谢异常诊断的临界值为3.55 mmol/L,敏感度为79.66%,特异度为87.94%,AUC为0.856(95%CI=0.825~0.886)。结论:孕前高BMI、有糖尿病家族史、孕中期TG>1.02 mmol/L和血清硒蛋白P>2.69 mmol/L是GDM孕妇产后糖代谢异常的危险因素,孕中期血清硒蛋白P对预测产后糖代谢异常有一定的价值。
Abstract:
Aim:To study the influencing factors of abnormal postpartum glucose metabolism in pregnant women with gestational diabetes mellitus and the predictive value of serum selenium protein P in mid-pregnancy.Methods:A total of 400 cases of pregnant women with gestational diabetes mellitus were retrospectively analyzed. The patients were allocated into normal glucose metabolism group(n=282)and abnormal glucose metabolism group(n=118)depending on the result of 75 g OGTT. The serum selenoprotein P and basic information of the two groups were compared, and the risk factors of abnormal glucose metabolism were analyzed by logistic regression analysis.Results:The level of serum selenoprotein P in the abnormal glucose metabolism group was significantly higher than that in the normal glucose metabolism group(P<0.05).The pre-pregnancy BMI, family history of diabetes, mellitus weight gain during pregnancy, triglyceride, high density lipoprotein and low density lipoprotein between the two groups had significant differences(P<0.05). Logistic regression analysis showed that pre-pregnancy BMI>24 kg/m2(OR=1.408, 95%CI=1.137-1.743), family history of diabetes mellitus(OR=1.718, 95%CI=1.443-2.045), TG>1.02 mmol/L in mid-pregnancy(OR=1.259,95%CI=1.182-1.340)and selenoprotein P>2.69 mmol/L in mid-pregnancy(OR=2.010,95%CI=1.168-3.459)were risk factors of abnormal postpartum glucose metablism in pregnant women with gestational diabetes mellitus. The critical value of serum selenoprotein P for the diagnosis of abnormal postpartum glucose metabolism was 3.55 mmol/L, the corresponding sensitivity was 79.66%, the specificity was 87.94% and the AUC was 0.856(95%CI=0.825-0.886).Conclusion:High BMI before pregnancy, family history of diabetes mellitus, TG>1.02 mmol/L and selenoprotein P>2.69 mmol/L in mid-pregnancy are risk factors for abnormal glucose metabolism in postpartum abnormal glucose metabolism women.Serum selenoprotein P in mid-pregnancy has certain clinical value in predicting postpartum abnormal glucose metabolism.

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备注/Memo

备注/Memo:
【基金项目】河南省医学科技攻关计划项目(201602076)
【作者简介】杨再刚,通信作者,男,1971年10月生,博士,主任医师,研究方向:糖尿病及其并发症,E-mail:zgyang028016@163.com
更新日期/Last Update: 2019-09-20