[1]孔慧娟,卜志勤,王 芳,等.25岁及以下女性体外受精胚胎移植助孕特征及结局分析[J].郑州大学学报(医学版),2019,(05):775-779.[doi:10.13705/j.issn.1671-6825.2019.060.057]
 KONG Huijuan,BU Zhiqin,WANG Fang,et al.Analysis of characteristics and outcome of in vitro fertilization and embryo transfer in women ≤25 years[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(05):775-779.[doi:10.13705/j.issn.1671-6825.2019.060.057]
点击复制

25岁及以下女性体外受精胚胎移植助孕特征及结局分析()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年05期
页码:
775-779
栏目:
应用研究
出版日期:
2019-09-20

文章信息/Info

Title:
Analysis of characteristics and outcome of in vitro fertilization and embryo transfer in women ≤25 years
作者:
孔慧娟卜志勤王 芳苏迎春
郑州大学第一附属医院生殖医学中心; 河南省生殖与遗传重点实验室 郑州 450052
Author(s):
KONG Huijuan BU Zhiqin WANG Fang SU Yingchun
Center for Reproductive Medicine, the First Affiliated Hospital,Zhengzhou University; Henan Key Laboratory of Reproduction and Genetics, Zhengzhou 450052
关键词:
体外受精 胚胎移植 超排卵 妊娠结局 女性年龄
Keywords:
fertilization in vitro embryo transfer controlled ovarian hyperstimulation pregnancy outcome the female age
分类号:
R714.7
DOI:
10.13705/j.issn.1671-6825.2019.060.057
摘要:
目的:分析行体外受精/卵胞浆内单精子显微注射(IVF/ICSI)的25岁及以下女性的助孕特征及结局。方法:回顾性分析第一周期行IVF/ICSI助孕的12 350例患者的临床资料,其中女性年龄20~岁522例,23~岁3 030例,26~30岁8 798例。比较3个年龄组患者的临床特征、助孕过程及妊娠结局。结果:3组不孕年限、男性因素不孕者占比、促性腺激素(Gn)用量和使用时间、HCG日雌二醇水平、ICSI占比差异均有统计学意义(P<0.05)。20~岁组、23~岁组促性腺激素(Gn)用量和使用时间均小于26~30岁组(P<0.05),20~岁组男性因素不孕者占比、HCG日雌二醇水平、ICSI占比大于26~30岁组(P<0.05); 23~岁组单个取卵周期活产率低于26~30岁组,全部周期累积活产率高于26~30岁组(P<0.05)。精子来源为丈夫射出且受精方式为IVF人群3组间单个取卵周期活产率和全部周期累积活产率差异无统计学意义(P>0.05)。结论:IVF/ICSI助孕时,20~岁、23~岁及26~30岁女性生育能力基本相同。
Abstract:
Aim:To analyze the outcome of women(≤25 years)received in vitro fertilization/introcytoplasmatic single sperm injection(IVF/ICSI)and their characteristics.Methods:A retrospective study was executed.A total of 12 350 women who received first cycle of IVF/ICSI were enrolled,522 cases were 20- years old(Group A), 3 030 cases were 23- years old(Group B), and 8 798 cased were 26-30 years old(Group C). Clinical characteristics,course and outcomes of IVF/ICSI in different groups were compared.Results:There were significant differences in infertility time, the proportion of males factors in infertility course,gonadotropin(Gn)dosage and time, the estrogens(E2)level on HCG day, and the proportion of ICSI among the 3 groups(P<0.05).The Gn dosage and time of Group A and B were lower than those of Group C(P<0.05).The proportion of males factors in infertility course, E2 level on HCG day,and the proportion of ICSI of Group A were higher than those of Group C(P<0.05).Compared with Group C, Group A had lower rate of live-birth rate and higher cumulative live-birth rate(P<0.05). The live-birth rate and cumulative live-birth rate were similar in three groups when only considering the women who accepted IVF with the sperm ejaculated from husband.Conclusion:Fertility of women aged 20- years, 23- years and 26-30 years are similar during IVF/ICSI.

参考文献/References:

[1] KISSIN DM,JAMIESON DJ,BARFIELD WD. Monitoring health outcomes of assisted reproductive technology[J].N Engl J Med 2014,371(1):91
[2] SMITH A,TILLING K,NELSON SM,et al. Live-birth rate associated with repeat in vitro fertilization treatment cycles[J].JAMA 2015,314(24):2654
[3] MALIZIA BA,HACKER MR,PENZIAS AS.Cumulative live-birth rates after in vitro fertilization[J].N Engl J Med,2009,360(3):236
[4] HUMM KC,DODGE LE,WU LH,et al.In vitro fertilization in women under 35: counseling should differ by age[J].J Assist Reprod Genet,2015,32(10):1449
[5] FRANASIAK JM,FORMAN EJ,HONG KH,et al.The nature of aneuploidy with increasing age of the female partner: a review of 15 169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening[J].Fertil Steril,2014,101(3):656
[6] NAZEMIAN Z,ESFANDIARI N,JAVED M,et al.The effect of age on in vitro fertilization outcome: is too young possible?[J].J Assist Reprod Genet,2011,28(2):101
[7] 张静,孙博,卜志勤,等.年龄对长方案体外受精-胚胎移植助孕的影响[J].国际生殖健康/计划生育杂志,2014(3):239
[8] HU L, BU Z, GUO Y, et al. Comparison of different ovarian hyperstimulation protocols efficacy in poor ovarian responders according to the Bologna criteria[J]. Int J Clin Exp Med,2014,7(4):1128
[9] KONG HJ,HU LL,NIE L,et al.A multi-center, randomized controlled clinical trial of the application of a shortened protocol of long-acting Triptorelin down-regulated prior to IVF/ICSI among patients with endometriosis: a protocol[J].Reprod Health,2018,15(1):213
[10]HAAF T,HAHN A,LAMBRECHT A,et al.A high oocyte yield for intracytoplasmic sperm injection treatment is associated with an increased chromosome error rate[J].Fertil Steril,2009,91(3):733
[11]ATA B, KAPLAN B, DANZER H, et al. Array CGH analysis shows that aneuploidy is not related to the number of embryos generated[J]. Reprod Biomed Online,2012,24(6):614
[12]GIANAROLI L,MAGLI MC,CAVALLINI G,et al.Predicting aneuploidy in human oocytes: key factors which affect the meiotic process[J].Hum Reprod,2010,25(9):2374
[13]SUNKARA SK,RITTENBERG V,RAINE-FENNING N,et al.Association between the number of eggs and live birth in IVF treatment: an analysis of 400 135 treatment cycles[J].Hum Reprod,2011,26(7):1768
[14]LABARTA E,BOSCH E,MERCADER A,et al.A higher ovarian response after stimulation for ivf is related to a higher number of euploid embryos[J].Biomed Res Int,2017. doi: 10.1155/2017/5637923.
[15]SENGUPTA P,BORGES J,DUTTA S,et al.Decline in sperm count in European men during the past 50 years[J].Hum Exp Toxicol,2018,37(3):247
[16]COOPER TG,NOONAN E,VON ECKARDSTEIN S,et al.World Health Organization reference values for human semen characteristics[J].Hum Reprod Update,2010,16(3):231
[17]宋文妍,王雪改,孙莹璞,等.三种促排卵方案对不同年龄子宫内膜异位症患者IVF-ET妊娠及出生结局的影响[J].郑州大学学报(医学版),2016,22(2):227
[18]ZHENG JF,LU YN,QU XQ,et al.Decreased sperm motility retarded ICSI fertilization rate in severe oligozoospermia but good-quality embryo transfer had achieved the prospective clinical outcomes[J].PLoS One,2016,11(9):e0163524
[19]MEHTA A,BOLYAKOV A,SCHLEGEL PN.Higher pregnancy rates using testicular sperm in men with severe oligospermia[J].Fertil Steril,2015,104(6):1382

相似文献/References:

[1]梁琳琳△,李杭生,何巧花,等.IVF周期中不同亚型多囊卵巢综合征不孕患者低剂量递增促排卵效果*[J].郑州大学学报(医学版),2012,(04):530.
 LIANG Linlin,LI Hangsheng,HE Qiaohua,et al.Comparison of clinical results of lowdose increasing ovarian stimulation in IVF patients with different subtype of polycystic ovary syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(05):530.
[2]海兰),谭丽)#,毛跟红),等.不同冷冻载体对小鼠成熟卵母细胞玻璃化冷冻的影响[J].郑州大学学报(医学版),2012,(04):550.
 HAI Lan,TAN Li,MAO Genhong,et al.Effect of different cryopreservative carriers on vitrification of mouse MⅡ oocytes[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2012,(05):550.

备注/Memo

备注/Memo:
【作者简介】苏迎春,通信作者,女,1965年1月生,硕士,主任医师,研究方向:生殖与内分泌,E-mail:suyingchun1@126.com
更新日期/Last Update: 2019-09-20