[1]张瑞涛,史惠蓉,刘哲颖,等.卵巢上皮性癌组织中miR-338-3p的表达[J].郑州大学学报(医学版),2019,(05):780-783.[doi:10.13705/j.issn.1671-6825.2018.08.124]
 ZHANG Ruitao,SHI Huirong,LIU Zheying,et al.Expression of miR-338-3p in epithelial ovarian cancer tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(05):780-783.[doi:10.13705/j.issn.1671-6825.2018.08.124]
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卵巢上皮性癌组织中miR-338-3p的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年05期
页码:
780-783
栏目:
应用研究
出版日期:
2019-09-20

文章信息/Info

Title:
Expression of miR-338-3p in epithelial ovarian cancer tissue
作者:
张瑞涛史惠蓉刘哲颖张微微姬鹏程王文文
郑州大学第一附属医院妇科 郑州 450052
Author(s):
ZHANG Ruitao SHI Huirong LIU Zheying ZHANG Weiwei JI Pengcheng WANG Wenwen
Department of Gynecology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
卵巢上皮性癌 微小RNA-338-3p 复发 预后
Keywords:
ovarian epithelial cancer miR-338-3p recurrence prognosis
分类号:
R737.31
DOI:
10.13705/j.issn.1671-6825.2018.08.124
摘要:
目的:检测微小RNA-338-3p(miR-338-3p)在卵巢上皮性癌组织中的表达情况,探讨其在卵巢癌发生发展中的作用。方法:采用qRT-PCR检测20例正常卵巢组织、20例良性卵巢上皮性肿瘤组织和65例卵巢上皮性癌组织中miR-338-3p的表达情况,分析卵巢上皮性癌与组织中miR-338-3p表达与临床病理指标的关系,Kaplan-Meier法分析miR-338-3p表达对卵巢癌患者生存的影响。结果:卵巢上皮性癌组织中miR-338-3p的表达显著低于正常卵巢组织和良性卵巢上皮性肿瘤组织(P<0.05)。临床分期晚、组织级别高、有淋巴结转移的卵巢上皮性癌组织中miR-338-3p表达低(P<0.05)。miR-338-3p表达水平相对较低的卵巢上皮性癌患者的总体生存率和无进展生存期明显短于miR-338-3p表达水平相对较高的患者(P<0.05)。结论:miR-338-3p低表达与卵巢癌患者预后不良有关,可作为卵巢癌预后的标记物。
Abstract:
Aim:To detect the expression of miR-338-3p in epithelial ovarian cancer tissue.Methods:The expressions of miR-338-3p in 20 specimens of normal ovary, 20 specimens of benign epithelial ovarian tumor and 65 specimens of epithelial ovarian cancer tissues were detected by qRT-PCR, and its association with the clinicopathologic characteristics of epithelial ovarian cancer was analyzed. The relation between miR-338-3p expression and the survival of ovarian cancer patients was measured by Kaplan-Meier analysis.Results:The expression of miR-338-3p in epithelial ovarian cancer tissue was obviously lower than those in normal ovarian tissue and benign ovarian tumor(P<0.05). In epithelial ovarian cancer, lower expression of miR-338-3p was associated with more advanced FIGO stage,higher histological grade and lymph node metastasis(P<0.05). The overall survival rate and progression free survival rate of patients with lower miR-338-3p were obviously shorter(P<0.05).Conclusion:Low expression of miR-338-3p is related with poor prognosis of ovarian cancer patients,and miR-338-3p could be served as a biomarker for the prognosis of ovarian cancer.

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备注/Memo

备注/Memo:
【作者简介】张瑞涛,男,1981年8月生,博士,副教授,副主任医师,研究方向:妇科恶性肿瘤,E-mail:fcczhangrt@zzu.edu.cn
更新日期/Last Update: 2019-09-20