[1]张 牧),易朝辉),杨红梅),等.丹参活性成分靶点分子网络的生物信息学预测[J].郑州大学学报(医学版),2019,(06):798-801.[doi:10.13705/j.issn.1671-6825.2019.01.035]
　ZHANG Mu),YI Zhaohui),YANG Hongmei),et al.Informatics-based prediction of molecular networks targeting active ingredients in Danshen(Salvia miltiorrhiza Bunge)[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(06):798-801.[doi:10.13705/j.issn.1671-6825.2019.01.035]
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丹参活性成分靶点分子网络的生物信息学预测()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年06期
页码:
798-801
栏目:
论著
出版日期:
2019-11-20

文章信息/Info

Title:
Informatics-based prediction of molecular networks targeting active ingredients in Danshen(Salvia miltiorrhiza Bunge)
作者:
张 牧1); 易朝辉2); 杨红梅3); 宋新强4);  代二琴4); 李开鸣4); 刘迎福5)
1)信阳师范学院医院 河南信阳 464000 2)信阳职业技术学院心理咨询室 河南信阳 464000 3)北京体育大学学术期刊社 北京 100084 4)信阳师范学院生命科学学院 河南信阳 464000 5)厦门大学医学院基础医学系 福建厦门 361005
Author(s):
ZHANG Mu1); YI Zhaohui2); YANG Hongmei3); SONG Xinqiang4); DAI Erqin4); LI Kaiming4); LIU Yingfu5)
1)The Hospital Affiliated to Xinyang Normal University,Xinyang,Henan 464000 2)Psychological Counseling Room,Xinyang Vocational and Technical College,Xinyang,Henan 464000 3)Academic Journals,Beijing Sport University,Beijing 100084 4)Department of Biological Sciences,Xinyang Normal University,Xinyang,Henan 464000 5)Department of Basic Medical Sciences,Medical College,Xiamen University,Fujian,Xiamen 361005
关键词:
丹参;  心血管疾病;  生物信息学分析;  分子网络
Keywords:
Salvia miltiorrhiza Bunge;  cardiovascular disease;  bioinformatics analysis;  molecular network
分类号:
R541
DOI:
10.13705/j.issn.1671-6825.2019.01.035
摘要:
目的:采用整合生物信息学方法预测丹参治疗心血管疾病的潜在机制。方法:从PubChem数据库中搜索丹参靶标蛋白,从NCBI数据库中搜索心血管疾病相关基因,利用IPA比较、分析搜索结果,预测丹参治疗心血管疾病的交互作用分子网络。结果:丹参治疗心血管疾病的靶标蛋白主要有FASN、 PAFAH1B2、PLA2G7、PAFAH1B3和IL-1β,这些蛋白主要涉及LXR/RXR活化、动脉粥样硬化、肝纤维化/肝星形细胞活化、急性反应期信号、FXR/RXR活化等信号传导通路; 交互作用分子网络主要涉及细胞运动、免疫细胞运输、血液系统发育,参与DNA的复制、重组和修复等。结论:预测了丹参治疗心血管疾病的几个蛋白质靶点以及参与的信号途径; 整合生物信息学方法可以用于分析小分子化学成分的作用机制。
Abstract:
Aim:To identify the possible mechanisms of Danshen(Salvia miltiorrhiza Bunge)treating cardiovascular disease using integrative bioinformatics method.Methods:Possible human proteins targeted by Danshen were identified in the PubChem database, possible human gene related with cardiovascular disease were identified in the NCBI database, and then both sets were analyzed using IPA(ingenuity pathway analysis)to predict molecular networks about Danshen in cardiovascular disease treatment.Results:The targeted proteins of Danshen in cardiovascular disease treatment included FASN, PAFAH1B2, PLA2G7, PAFAH1B3 and IL1B, and they were involved primarily in LXR/RXR activation, atherosclerosis signaling transduction, hepatic fibrosis/hepatic stellate cell activation, acute phase response signaling, FXR/RXR activation. The main action networks were predicted to be involved in cellular movement, immune cell trafficking, hematological system development, and DNA replication, recombination, and repair.Conclusion:Several specific proteins and pathways of Danshen in cardiovascular disease treatment have been predicted, and integrative bioinformatics analysis has showed the power in chemical fragment mechanistic studies.

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金项目(U1804179); 河南省创新型科技团队项目(2017083) 【作者简介】宋新强,通信作者,男,1974年5月生,博士,副教授,研究方向:中药靶点筛选,E-mail:xqsong2012@126.com
更新日期/Last Update: 2019-11-20