[1]张素兰,杨道科,左笑笑,等.热疗辅助放疗治疗晚期肝癌的疗效[J].郑州大学学报(医学版),2019,(06):906-908.[doi:10.13705/j.issn.1671-6825.2018.07.128]
 ZHANG Sulan,YANG Daoke,ZUO Xiaoxiao,et al.Efficacy of hyperthermia assisted radiotherapy on patients with advanced liver cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(06):906-908.[doi:10.13705/j.issn.1671-6825.2018.07.128]
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热疗辅助放疗治疗晚期肝癌的疗效()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2019年06期
页码:
906-908
栏目:
应用研究
出版日期:
2019-11-20

文章信息/Info

Title:
Efficacy of hyperthermia assisted radiotherapy on patients with advanced liver cancer
作者:
张素兰杨道科左笑笑刘倩倩王佳琪李利铭
郑州大学第一附属医院肿瘤医院 郑州 450052
Author(s):
ZHANG SulanYANG DaokeZUO XiaoxiaoLIU QianqianWANG JiaqiLI Liming
Tumor Hospital,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052
关键词:
晚期肝癌 热疗 放疗
Keywords:
advanced liver cancer hyperthermia radiotherapy
分类号:
R735.7
DOI:
10.13705/j.issn.1671-6825.2018.07.128
摘要:
目的:观察热疗辅助放疗治疗晚期肝癌的疗效。方法:63例晚期肝癌患者给予单纯放疗(对照组),63例晚期肝癌患者给予放疗联合体外局部高频热疗(观察组)。放疗为采用CT辅助定位、直线加速器6 MV-X射线进行体外照射,总放射剂量为36~60 Gy。热疗为体外局部高频热疗,温度设为40~43 ℃,持续30 min,2次/周,热疗时机为放疗结束后1 h内,共给予7~12次热疗。比较两组患者治疗1~2个月的总有效率、不良反应发生率、生活质量(KPS评分)及1 a生存率和复发率。结果:观察组治疗有效率(88.9%)高于对照组(68.3%),多种不良反应的发生率均低于对照组(P<0.05); 观察组KPS评分高于对照组(P<0.05); 观察组1 a生存率高于对照组,1 a复发率低于对照组(P<0.05)。结论:与单纯放疗比,热疗辅助放疗可改善晚期肝癌患者预后。
Abstract:
Aim:To analyze the effects of hyperthermia assisted radiotherapy on patients with advanced liver cancer.Methods:A total of 126 patients with advanced liver cancer were selected as subjects,among whom,63 were treated with radiotherapy alone(control group)and 63 were treated with radiotherapy combined with extracorporeal local high frequency hyperthermia(observation group). Radiotherapy was performed by external irradiation with CT assisted localization and linear accelerator(6 MV-X), and the total radiation dose was 36~60 Gy. In vitro local high-frequency hyperthermia was performed after radiotherapy with the temperature of 40~43 ℃ for 30 min after reaching the set temperature,the heat treatment frequency was twice per week,and the patients were given a total of 7~12 times of hyperthermia accordingly. The respond rate, the incidence of adverse reactions,the KPS scores as well as 1-year survival rate and recurrence rate were compared between the two groups.Results:The total respond rate of the control group was 68.3%, lower than that(88.9%)of the observation group,and the incidence of adverse reactions of the observation group was lower than that of the control group(P<0.05). Compared with the control group, the KPS scores of the observation group were higher,the 1-year survival rate was higher,and the 1-year recurrence rate was lower(P<0.05).Conclusion:Radiotherapy combined with extracorporeal local high frequency hyperthermia can obviously improve the clinical efficiency of the patients with advanced liver cancer.

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备注/Memo

备注/Memo:
【作者简介】杨道科,通信作者,男,1966年10月生,主任医师,教授,研究方向:肿瘤放疗、热疗及肿瘤综合治疗,E-mail:15903650068@163.com
更新日期/Last Update: 2019-11-20