[1]薛伍君),陈清江),张旭东),等.弥漫大B细胞淋巴瘤组织中PCDH10的表达[J].郑州大学学报(医学版),2020,(06):819-822.[doi:10.13705/j.issn.1671-6825.2020.01.045]
　XUE Wujun),CHEN Qingjiang),ZHANG Xudong),et al.Expression of PCDH10 in diffuse large B cell lymphoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2020,(06):819-822.[doi:10.13705/j.issn.1671-6825.2020.01.045]
点击复制

弥漫大B细胞淋巴瘤组织中PCDH10的表达()
分享到：

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2020年06期
页码:
819-822
栏目:
应用研究
出版日期:
2020-11-20

文章信息/Info

Title:
Expression of PCDH10 in diffuse large B cell lymphoma tissue
作者:
薛伍君1); 陈清江1); 张旭东2); 张明智2); 陈国荣1); 吴少璇2); 尹美凤2); 杨万秋1); 王进隆1); 吴晓爽1)
1)新乡医学院第三附属医院肿瘤科 河南新乡453000 2)郑州大学第一附属医院肿瘤科 郑州450052
Author(s):
XUE Wujun1); CHEN Qingjiang1); ZHANG Xudong2); ZHANG Mingzhi2); CHEN Guorong1); WU Shaoxuan2); YIN Meifeng2); YANG Wanqiu1); WANG Jinlong1); WU Xiaoshuang1); TANG Canwei1); LI Chong1)
1)Department of Oncology,the Third Affiliated Hospital,Xinxiang Medical University,Xinxiang,Henan 453000 2)Department of Oncology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
弥漫大B细胞淋巴瘤;  原钙黏蛋白10;  预后
Keywords:
diffuse large B cell lymphoma;  protocadherin 10;  prognosis
分类号:
R733.4
DOI:
10.13705/j.issn.1671-6825.2020.01.045
摘要:
目的:探讨原钙黏蛋白10(PCDH10)在弥漫大B细胞淋巴瘤(DLBCL)组织中的表达及临床意义。方法:采用免疫组化SP法检测55例DLBCL组织(DLBCL组)和23例炎性增生淋巴结组织(炎性组)中PCDH10的表达,并结合患者临床资料进行分析。结果:DLBCL组PCDH10的阳性表达率为29.1%,低于炎性组(65.2%)(P=0.003)。DLBCL组织中PCDH10的表达与LDH水平、Ki-67、Ann Arbor分期和国际预后评分指数(IPI)均有关(P<0.05),而与患者的性别、年龄、有无骨髓侵犯无关(P>0.05)。DLBCL组织中PCDH10阳性表达率随Ann Arbor分期进展和IPI增加均呈下降趋势(P<0.05)。结论:PCDH10在DLBCL组织中低表达,其低表达与DLBCL的恶性程度及不良预后有关,可为病情和预后评估提供一定的参考。
Abstract:
Aim:To investigate the expression and clinical significance of protocadherin 10(PCDH10)in diffuse large B cell lymphoma(DLBCL)tissue.Methods: Immunohistochemical SP method was used to detect the expression of PCDH10 in 55 cases of DLBCL tissue(DLBCL group)and 23 cases of proliferative lymph node tissue(inflammation group),and clinical data of patients were combined for analysis.Results: The positive rate of PCDH10 expression in the DLBCL group was 29.1%,which was significantly lower than that(65.2%)of the inflammation group(P<0.05).The positive expression of PCDH10 in the DLBCL tissue was related to LDH,Ki-67,Ann Arbor staging,and International Prognosis Index(IPI)(P<0.05),but not related to gender,age,or presence of bone marrow invasion(P>0.05).The PCDH10 positive expression rate in the DLBCL tissue showed a downward trend with the progress of Ann Arbor staging and the increase in IPI(P<0.05).Conclusion: PCDH10 is lowly expressed in DLBCL tissue,and its low expression is related to the malignant degree and bad prognosis of DLBCL,which can provide a certain reference for disease condition and prognosis assessment.

参考文献/References:

[1] LI S,YOUNG KH,MEDEIROS LJ.Diffuse large B-cell lymphoma[J].Pathology,2018,50(1):74
[2] MIYAZAKI K.Treatment of diffuse large B-cell lymphoma[J].J Clin Exp Hematop,2016,56(2):79
[3] 卢学春,于力.难治性淋巴瘤的药物治疗进展[J].解放军医学杂志,2008,33(10):1272
[4] ECHIZEN K,NAKADA M,HAYASHI T,et al.PCDH10 is required for the tumorigenicity of glioblastoma cells[J].Biochem Biophys Res Commun,2014,444(1):13
[5] LIU W,WU J,SHI G,et al.Aberrant promoter methylation of PCDH10 as a potential diagnostic and prognostic biomarker for patients with breast cancer[J].Oncol Lett,2018,16(4):4462
[6] BHAT S,KABEKKODU SP,VARGHESE VK,et al.Aberrant gene-specific DNA methylation signature analysis in cervical cancer[J].Tumour Biol,2017,39(3):1010428317694573
[7] YE M,LI J,GONG J.PCDH10 gene inhibits cell proliferation and induces cell apoptosis by inhibiting the PI3K/Akt signaling pathway in hepatocellular carcinoma cells[J].Oncol Rep,2017,37(6):3167
[8] QIU C,BU X,JIANG Z.Protocadherin-10 acts as a tumor suppressor gene,and is frequently downregulated by promoter methylation in pancreatic cancer cells[J].Oncol Rep,2016,36(1):383
[9] WONG DOO N,MAKALIC E,JOO JE,et al.Global measures of peripheral blood-derived DNA methylation as a risk factor in the development of mature B-cell neoplasms[J].Epigenomics,2016,8(1):55
[10]NARAYAN G,XIE D,FREDDY AJ,et al.PCDH10 promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis[J].Genes Chromosomes Cancer,2013,52(11):1030
[11]NARAYAN G,FREDDY AJ,XIE D,et al.Promoter methylation-mediated inactivation of PCDH10 in acute lymphoblastic leukemia contributes to chemotherapy resistance[J].Genes Chromosomes Cancer,2011,50(12):1043
[12]SHI D,MURTY VV,GU W.PCDH10,a novel p53 transcriptional target in regulating cell migration[J].Cell Cycle,2015,14(6):857
[13]胡俊霞,陈清江,张旭东,等.PD-1/PD-Ls在EBV阳性T/NK淋巴组织增殖性疾病中的表达及临床意义[J].中国肿瘤临床,2018,45(24):1248
[14]ZHONG X,SHEN H,MAO J,et al.Epigenetic silencing of protocadherin 10 in colorectal cancer[J].Oncol Lett,2017,13(4):2449
[15]MORROW EM,YOO SY,FLAVELL SW,et al.Identifying autism loci and genes by tracing recent shared ancestry[J].Science,2008,321(5886):218
[16]TSAI NP,WILKERSON JR,GUO W,et al.Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95[J].Cell,2012,151(7):1581
[17]YANG Y,JIANG Y,JIANG M,et al.Protocadherin 10 inhibits cell proliferation and induces apoptosis via regulation of DEP domain containing 1 in endometrial endometrioid carcinoma[J].Exp Mol Pathol,2016,100(2):344
[18]田浩,马翾,高峡.PCDH10在胃癌组织中的表达特点及其与患者临床特征、预后的关系[J].癌症进展,2019,17(3):338
[19]BING Y,TIAN M,LI G,et al.Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients[J].Medicine(Baltimore),2018,97(35):e12055
[20]QI Y,OOI HS,WU J,et al.MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10[J].Oncotarget,2016,7(11):12693
[21]HARADA H,MIYAMOTO K,YAMASHITA Y,et al.Prognostic signature of protocadherin 10 methylation in curatively resected pathological stage Ⅰ non-small-cell lung cancer[J].Cancer Med,2015,4(10):1536
[22]ZHOU LN,HUA X,DENG WQ,et al.PCDH10 interacts with hTERT and negatively regulates telomerase activity[J].Medicine(Baltimore),2015,94(50):e2230

相似文献/References:

[1]葛菊蕊),孙振昌),张旭东),等.Hp感染对原发胃弥漫大B细胞淋巴瘤治疗及预后的影响[J].郑州大学学报(医学版),2020,(02):154.[doi:10.13705/j.issn.1671-6825.2019.12.222]
　GE Jurui),SUN Zhenchang),ZHANG Xudong),et al.Effects of Hp infection on treatment and prognosis of primary gastric diffuse large B-cell lymphoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2020,(06):154.[doi:10.13705/j.issn.1671-6825.2019.12.222]
[2]李佳音,张明智.DA-EPOCHR方案与ESHAPR方案治疗复发难治性弥漫大B细胞淋巴瘤效果比较[J].郑州大学学报(医学版),2020,(04):584.[doi:10.13705/j.issn.1671-6825.2019.07.134]
　LI Jiayin,ZHANG Mingzhi.Efficacy of DA-EPOCHR regimen and ESHAPR regimen in treatment of relapsed or refractory diffuse large B-cell lymphoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2020,(06):584.[doi:10.13705/j.issn.1671-6825.2019.07.134]

备注/Memo

备注/Memo:
【基金项目】国家自然科学基金青年项目(81700187)
【作者简介】陈清江,通信作者,男,1969年12月生,博士,教授,研究方向:淋巴瘤的基础与临床研究,E-mail:qingjiang_c@126.com
更新日期/Last Update: 2020-11-20