[1]李强明,张国庆,侯志超,等.淋巴结清扫数目对高龄(≥80岁)食管癌患者生存的影响:基于SEER数据库分析[J].郑州大学学报(医学版),2020,(06):866-869.[doi:10.13705/j.issn.1671-6825.2019.10.038]
 LI Qiangming,ZHANG Guoqing,HOU Zhichao,et al.A prognostic analysis on the number of lymph node resection for the elderly patients(aged ≥80 years)with esophageal cancer based on a SEER database[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2020,(06):866-869.[doi:10.13705/j.issn.1671-6825.2019.10.038]
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淋巴结清扫数目对高龄(≥80岁)食管癌患者生存的影响:基于SEER数据库分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2020年06期
页码:
866-869
栏目:
应用研究
出版日期:
2020-11-20

文章信息/Info

Title:
A prognostic analysis on the number of lymph node resection for the elderly patients(aged ≥80 years)with esophageal cancer based on a SEER database
作者:
李强明张国庆侯志超刘旭东刘天阳赵 松李向楠
郑州大学第一附属医院胸外科 郑州 450052
Author(s):
LI QiangmingZHANG GuoqingHOU ZhichaoLIU XudongLIU TianyangZHAO SongLI Xiangnan
Department of Thoracic Surgery,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
食管癌 高龄 淋巴结清扫 SEER
Keywords:
esophageal cancer octogenarian lymph node dissection SEER
分类号:
R571
DOI:
10.13705/j.issn.1671-6825.2019.10.038
摘要:
目的:探讨淋巴结清扫的数目对高龄(≥80岁)食管癌患者预后的影响。方法:选取美国SEER数据库中1998年1月1日至2016年12月31日行食管癌根治术加淋巴结清扫的高龄食管癌患者的临床资料。共225例患者纳入本研究,根据淋巴结清扫的数目将患者分为A组(清扫1~14枚淋巴结,153例)和 B组(清扫≥15枚淋巴结,72例)。比较两组患者的预后。结果:两组患者30、60和90 d围手术期死亡率的差异均无统计学意义(P>0.05),术后5 a 总生存和肿瘤特异性生存曲线的差异亦无统计学意义(P>0.05)。结论:高龄食管癌(≥80岁)患者不能从广泛淋巴结清扫中获益。
Abstract:
Aim:To explore the prognostic value of the number of lymph node resection for the elderly patients(aged ≥80 years)with esophageal cancer.Methods:The SEER database was examined for surgically resected esophageal carcinoma and included the elderly patients(aged ≥80 years)from 1998 to 2016.A total of 225 octogenarians with esophageal cancer underwent esophagectomy with ≥1 lymph node dissection were enrolled in the analysis.The patients were divided into two groups according to the number of dissected lymph nodes:group A(1-14 lymph nodes,153 patients)and group B(≥15 lymph nodes,72 patients),respectively.The overall survival and tumor-specific survival after esophagectomy with lymph node dissection were analyzed.Results:There was no significant difference in terms of 30,60 and 90 day postoperative mortality between the two groups(P>0.05).There was no statistical difference in terms of overall survival or tumor-specific survival between the two groups(P>0.05).Conclusion:The octogenarians with esophageal cancer can not benefit from extensive lymph node dissection.

参考文献/References:

[1] FAIZ Z,LEMMENS VE,SIERSEMA PD,et al.Increased resection rates and survival among patients aged 75 years and older with esophageal cancer:a Dutch nationwide population-based study[J].World J Surg,2012,36(12):2872
[2] PAULUS E,RIPAT C,KOSHENKOV V,et al.Esophagectomy for cancer in octogenarians:should we do it? [J].Langenbecks Arch Surg,2017,402(3):539
[3] RUOL A,PORTALE G,CASTORO C,et al.Management of esophageal cancer in patients aged over 80 years [J].Eur J Cardiothorac Surg,2007,32(3):445
[4] MOSKOVITZ AH,RIZK NP,VENKATRAMAN E,et al.Mortality increases for octogenarians undergoing esophagogastrectomy for esophageal cancer [J].Ann Thorac Surg,2006,82(6):2031
[5] ALEXIOU C,BEGGS D,SALAMA FD,et al.Surgery for esophageal cancer in elderly patients:the view from Nottingham [J].J Thorac Cardiovasc Surg,1998,116(4):545
[6] ADAM DJ,CRAIG SR,SANG CT,et al.Esophagectomy for carcinoma in the octogenarian [J].Ann Thorac Surg,1996,61(1):190
[7] RIZK NP,ISHWARAN H,RICE TW,et al.Optimum lymphadenectomy for esophageal cancer [J].Ann Surg,2010,251(1):46
[8] XIA W,LIU S,MAO Q,et al.Effect of lymph node examined count on accurate staging and survival of resected esophageal cancer [J].Thorac Cancer,2019,10(5):1149
[9] ALLUM WH,BLAZEBY JM,GRIFFIN SM,et al.Guidelines for the management of oesophageal and gastric cancer[J].Gut,2011,60(11):1449
[10]BOUVIER AM,LAUNOY G,LEPAGE C,et al.Trends in the management and survival of digestive tract cancers among patients aged over 80 years [J].Aliment Pharmacol Ther,2005,22(3):233
[11]XU C,XI M,MORENO A,et al.Definitive chemoradiation therapy for esophageal cancer in the elderly:clinical outcomes for patients exceeding 80 years old [J].Int J Radiat Oncol Biol Phys,2017,98(4):811
[12]郭朝晖,张树亮,郑斌,等.高龄食管癌患者的胸、腹腔镜联合手术治疗[J].中华胸心血管外科杂志,2015,31(3):164
[13]TAKEUCHI H,MIYATA H,GOTOH M,et al.A risk model for esophagectomy using data of 5354 patients included in a Japanese nationwide web-based database [J].Ann Surg,2014,260(2):259
[14]BLENCOWE NS,STRONG S,MCNAIR AG,et al.Reporting of short-term clinical outcomes after esophagectomy:a systematic review [J].Ann Surg,2012,255(4):658

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备注/Memo

备注/Memo:
【基金项目】河南省科技厅科技攻关项目(172102310047); 郑州大学学科建设重点专项(XKZDQY202006)
【作者简介】李向楠,通信作者,男,1977年5月生,博士,副教授,博士研究生导师,研究方向:食管癌,E-mail:lxn-2000@163.com
更新日期/Last Update: 2020-11-20