[1]何谦益),石晓娟),连晶瑶),等.急性脑梗死患者外周血髓源抑制性细胞比例与预后的关系[J].郑州大学学报(医学版),2021,(01):108-112.
　HE Qianyi),SHI Xiaojuan),LIAN Jingyao),et al.Relationship between myeloid-derived suppressor cells proportion in peripheral blood and prognosis in peripheral blood patients with acute ischemic stroke[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2021,(01):108-112.
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急性脑梗死患者外周血髓源抑制性细胞比例与预后的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2021年01期
页码:
108-112
栏目:
应用研究
出版日期:
2021-01-20

文章信息/Info

Title:
Relationship between myeloid-derived suppressor cells proportion in peripheral blood and prognosis in peripheral blood patients with acute ischemic stroke
作者:
何谦益1; 2); 石晓娟1; 3; 4); 连晶瑶1; 3; 4); 刘莎莎1; 3; 4); 张 毅1; 3; 4; 5)
1)郑州大学第一附属医院生物细胞治疗中心 郑州 450052 2)郑州大学第一附属医院神经内二科 郑州 450052 3)郑州大学第一附属医院肿瘤中心 郑州 450052 4)河南省肿瘤免疫与生物治疗重点实验室 郑州 450052 5)郑州大学生命科学学院 郑州450001
Author(s):
HE Qianyi1; 2); SHI Xiaojuan1; 3; 4); LIAN Jingyao1; 3; 4); LIU Shasha1; 3; 4); ZHANG Yi1; 3; 4; 5)
1)Biotherapy Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500522)The Second Department of Neurology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 3)Cancer Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 4500524)Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou 4500525)School of Life Sciences, Zhengzhou University, Zhengzhou 450001
关键词:
急性脑梗死;  髓源抑制性细胞;  预后
Keywords:
acute ischemic stroke;  myeloid-derived suppressor cell;  prognosis
分类号:
R743.3
摘要:
目的:探讨髓源抑制性细胞(MDSC)与急性脑梗死预后的关系。方法:采集128例急性脑梗死患者以及100例健康对照外周血进行流式细胞学检测并分析MDSC的比例。用改良Rankin评分评价急性脑梗死患者随访90 d的预后(0～2分为预后好,3～5分为预后差)。分析预后好组(n=51)与预后差组(n=77)临床参数之间的差异,采用logistic 回归分析影响急性脑梗死预后的因素,采用ROC曲线评价患者外周血MDSC比例对患者预后的预测价值。结果:与健康对照组比较,急性脑梗死组外周血中多形核MDSC(PMN-MDSC)以及单核MDSC(M-MDSC)的比例上调(P<0.05)。与预后差组相比,预后好组急性脑梗死患者外周血中PMN-MDSC以及M-MDSC的比例上调(P<0.05)。PMN-MDSC与M-MDSC比例是影响急性脑梗死患者预后的危险因素。PMN-MDSC比例预测急性脑梗死患者预后的AUC为0.619(95%CI为0.519～0.720),截断值是4.220,敏感度为0.588,特异度为0.636; M-MDSC比例的AUC为0.747(95%CI为0.661～0.833),截断值是1.410,敏感度为0.784,特异度为0.623。结论:MDSC比例在急性脑梗死患者外周血中增加,并且可以作为患者的预后判断指标。
Abstract:
Aim:To investigate the relationship between myeloid-derived suppressor cell(MDSC)and the prognosis in patients with acute ischemic stroke.Methods:Flow cytometry was performed on 128 patients with acute ischemic stroke and 100 healthy controls to investigate the difference in the proportion of MDSC.Prognosis was evaluated using modified Rankin scale after 90 days of follow-up(0 to 2 scores means good recovery, while 3 to 5 scores means poor recovery).The difference between patients with good recovery(n=51)and poor recovery(n=77)was analyzed.Logistic regression analysis was used to search the factors that affected the prognosis of acute ischemic stroke.ROC curve was used to evaluate the prognostic value of the peripheral blood MDSC proportion.Results:Compared with healthy control group, the proportions of polymorphonuclear MDSC(PMN-MDSC)and monocytic MDSC(M-MDSC)in peripheral blood of patients in acute ischemic stroke group all increased(P<0.05).Compared with the group of patients with poor recovery, the proportions of PMN-MDSC and M-MDSC in peripheral blood of patients with good recovery increased(P<0.05).The PMN-MDSC and M-MDSC proportions were risk factors for prognosis of acute ischemic stroke patients.The AUC of the PMN-MDSC proportion was 0.619(95%CI was 0.519-0.720)when the cut-off was 4.220, the sensitivity was 0.588 and the specificity was 0.636.The AUC of M-MDSC proportion was 0.747(95%CI was 0.661-0.833)when the cut-off was 1.410, the sensitivity was 0.784 and the specificity was 0.623.Conclusion:MDSC proportion increases in peripheral blood of patients with acute ischemic stroke, and is related to the prognosis.

参考文献/References:

[1] RAYASAM A,HSU M,KIJAK JA,et al.Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?[J].Immunology,2018,154(3):363
[2] YAO T,LU W,ZHU J,et al.Role of CD11b+Gr-1+ myeloid cells in AGEs-induced myocardial injury in a mice model of acute myocardial infarction[J].Int J Clin Exp Pathol,2015,8(3):3238
[3] WANG YG,XIONG X,CHEN ZY,et al.Expansion of myeloid-derived suppressor cells in patients with acute coronary syndrome[J].Cell Physiol Biochem,2015,35(1):292
[4] PEGUES M,MCWILLIAMS IL,SZALAI AJ.C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame?[J].Am J Physiol Renal Physiol,2016,311(1):F176
[5] YAN JJ,RYU JH,PIAO H,et al.Granulocyte colony-stimulating factor attenuates renal ischemia-reperfusion injury by inducing myeloid-derived suppressor cells[J].J Am Soc Nephrol,2020,31(4):731
[6] KIM JA,MARCH K,CHAE HD,et al.Muscle-derived Gr1dimCD11b+ cells enhance neovascularization in an ischemic hind limb mouse model[J].Blood,2010,116(9):1623
[7] KAWANO T.Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)in ischemic stroke in mice[J].PLoS One,2019,5(14):e215482
[8] DEMEESTERE J,SCHELDEMAN L,CORNELISSEN S,et al.Alberta stroke program early CT score versus computed tomographic perfusion to predict functional outcome after successful reperfusion in acute ischemic stroke[J].Stroke,2018,49(10):2361
[9] MALONE K,AMU S,MOORE AC,et al.The immune system and stroke: from current targets to future therapy[J].Immunol Cell Biol,2019,97(1):5
[10]VEGLIA F,PEREGO M,GABRILOVICH D.Myeloid-derived suppressor cells coming of age[J].Nat Immunol,2018,19(2):108
[11]GABRILOVICH D.Myeloid-derived suppressor cells[J].Cancer Immunol Res,2017,5(1):3
[12]HIGAKI A,CAILLON A,PARADIS P,et al.Innate and innate-like immune system in hypertension and vascular injury[J].Curr Hypertens Rep,2019,21(1):4
[13]FLYNN MC,PERNES G,LEE M,et al.Monocytes, macrophages, and metabolic disease in atherosclerosis[J].Front Pharmacol,2019,10:666
[14]FOKS AC,VAN PG,WOLBERT J,et al.CD11b+Gr-1+ myeloid-derived suppressor cells reduce atherosclerotic lesion development in LDLr deficient mice[J].Cardiovasc Res,2016,111(3):252
[15]FERNÁNDEZ-RUIZ JC,GALINDO-DE ÁJ,MARTÍNEZ-FIERRO ML,et al.Myeloid-derived suppressor cells show different frequencies in diabetics and subjects with arterial hypertension[J].J Diabetes Res,2019.doi:10.1155/2019/1568457

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金-河南联合基金重点项目(U180481)
【作者简介】张毅,通信作者,男,1964年4月生,博士,教授,主任医师,研究方向:肿瘤免疫治疗的机制和临床转化,E-mail:yizhang@zzu.edu.cn
更新日期/Last Update: 2021-02-15