[1]申春艳,张建瑞,杜姗姗,等.单卵裂期胚胎移植第2天及第3天细胞数与妊娠率的关系[J].郑州大学学报(医学版),2021,(01):119-122.
 SHEN Chunyan,ZHANG Jianrui,DU Shanshan,et al.Relationship of embryo blastomere number at day 2 and 3 and pregnancy rate after IVF-ET[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2021,(01):119-122.
点击复制

单卵裂期胚胎移植第2天及第3天细胞数与妊娠率的关系()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2021年01期
页码:
119-122
栏目:
应用研究
出版日期:
2021-01-20

文章信息/Info

Title:
Relationship of embryo blastomere number at day 2 and 3 and pregnancy rate after IVF-ET
作者:
申春艳张建瑞杜姗姗张玉超周鹏飞刘 景王兴玲
郑州大学第三附属医院生殖医学中心 郑州 450052
Author(s):
SHEN ChunyanZHANG JianruiDU ShanshanZHANG Yuchao ZHOU Pengfei LIU Jing WANG Xingling
Reproductive Center,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
辅助生殖技术 临床妊娠率 继续妊娠率 胚胎细胞数
Keywords:
assisted reproductive technology clinical pregnancy rate ongoing pregnancy rate blastomere number
分类号:
R714.8
摘要:
目的:观察新鲜移植周期单卵裂期移植胚胎细胞数与临床妊娠率及继续妊娠率的关系。方法:选择进行新鲜周期单卵裂期胚胎移植的560例患者,观察移植第2、3天胚胎细胞数及第2天至第3天的细胞增长数,探讨其与临床妊娠率及继续妊娠率的关系。结果:移植第3天胚胎细胞数为8个细胞(C)和≥10C时,第2天细胞数为4C时,第2天至第3天细胞增长为4C时,临床妊娠率及继续妊娠均高于其他细胞数组(P<0.001)。第2天=4C且第3天=8C的胚胎临床妊娠率和继续妊娠率最高。结论:单卵裂期胚胎移植第2天为4C且第3天为8C时临床结局最优。
Abstract:
Aim:To observe the relationship between the number of cells transferred in single cleavage stage of fresh transfer cycle and clinical pregnancy rate and continued pregnancy rate.Methods:A total of 560 cases accepted fresh cycle single cleavage embryo transfer were selected. The number of embryo cells and cell growth on the 2nd and 3rd day of embryo transfer were observed, and the relationship between them and clinical pregnancy rate and continued pregnancy rate was discussed.Results:The clinical pregnancy rate and continued pregnancy rate of patients with 8 cells(C)and ≥10C on the 3rd day, 4C on the 2nd day and 4C of cell growth from the 2nd to the 3rd day were higher than those of other cell groups(P<0.001). The clinical pregnancy rate and continued pregnancy rate of patients with 8C on the 3rd day and 4C on the 2nd day were the highest(P<0.05).Conclusion:The best choice of single cleavage embryo transfer is 4C on the 2nd day and 8C on the 3rd day.

参考文献/References:

[1] CUTTING R.Single embryo transfer for all[J].Best Pract Res Clin Obstet Gynaecol, 2018,53:30
[2] WANG S, CHEN L, FANG J, et al.Comparison of the pregnancy and obstetric outcomes between single cleavage-stage embryo transfer and single blastocyst transfer by time-lapse selection of embryos[J].Gynecol Endocrinol,2019,35(9):792
[3] BARBERET J, BRUNO C, VALOT E,et al.Can novel early non-invasive biomarkers of embryo quality be identified with time-lapse imaging to predict live birth[J].Hum Reprod, 2019,34(8):1439
[4] KIMELMAN D, CONFINO R, OKEIGWE I, et al.Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population[J].J Assist Reprod Genet,2019,36(8):1561
[5] ZIEBE S, PETERSEN K, LINDENBERG S, et al.Embryo morphology or cleavage stage: how to select the best embryos for transfer after in-vitro fertilization[J].Hum Reprod, 1997,12(7):1545
[6] RACOWSKY C, COMBELLES CM, NUREDDIN A, et al.Day 3 and day 5 morphological predictors of embryo viability[J].Reprod Biomed Online,2003,6(3):323
[7] 孙青, 黄国宁, 孙海翔, 等.胚胎实验室关键指标质控专家共识[J].生殖医学杂志, 2018, 27(9): 836
SUN Q,HUANG GN,SUN HX,et al.CSRM consensus on key indicators for quality control in IVF laboratory[J].Journal of reproductive medicine, 2018,27(9):836
[8] ALPHA SCIENTISTS IN REPRODUCTIVE MEDICINE AND ESHRE SPECIAL INTEREST GROUP OF EMBRYOLOGY.The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting[J].Hum Reprod,2011,26(6):1270
[9] RHENMAN A, BERGLUND L, BRODIN T, et al.Which set of embryo variables is most predictive for live birth? A prospective study in 6252 single embryo transfers to construct an embryo score for the ranking and selection of embryos[J].Hum Reprod,2015,30(1):28
[10]刘群, 胡娟, 陈雯.D3低形态学评分胚胎的继续培养及其意义[J].中国妇幼保健, 2012,27(31):4945
LIU Q,HU J,CHEN W.Further culture of D3 embryos with low morphological score and the significance[J].Maternal and Child Health Care of China,2012,27(31):4945
[11]廖桂芝,丁洁,顾斌,等.体外受精胚胎细胞数量和碎片比例对囊胚形成的影响[J].生殖与避孕, 2015, 35(12): 879
LIAO GZH,DING J,GU B,et al.Influence of cell number and fragment to blastula formation during in vitro fertilization-embryo transfer treatment[J].Chinese Journal of Reproduction and Contraception,2015,35(12):879
[12]WONG C, CHEN AA, BEHR B, et al.Time-lapse microscopy and image analysis in basic and clinical embryo development research[J].Reprod Biomed Online,2013,26(2):120

相似文献/References:

[1]戴善军,杨 杰,王 芳,等.抗苗勒管激素水平及促性腺激素剂量与体外受精胚胎移植妊娠结局的关系[J].郑州大学学报(医学版),2021,(01):42.
 DAI Shanjun,YANG Jie,WANG Fang,et al.Relationship between anti-Mllerian hormone level, gonadotropin dose and pregnancy outcome of women accepted in vitro fertilization and embryo transfer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2021,(01):42.

备注/Memo

备注/Memo:
【基金项目】河南省重点研发与推广专项(182102310408); 河南省医学科技攻关计划项目(SB201902021)
【作者简介】王兴玲,通信作者,女,1962年2月生,博士,主任医师,教授,研究方向:生殖内分泌与辅助生殖,E-mail:wangxl208@126.com
更新日期/Last Update: 2021-02-15