[1]李晓丽)△,林锐),李建生),等. 不同胃黏膜病变组织中诱导型一氧化氮合酶mRNA的表达[J].郑州大学学报(医学版),2011,(03):413.
 LI Xiaoli,LIN Rui,LI Jiansheng),et al. Expression of inducible nitric oxide synthase mRNA in various gastric changes tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(03):413.
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 不同胃黏膜病变组织中诱导型一氧化氮合酶mRNA的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年03期
页码:
413
栏目:
论著
出版日期:
2011-05-15

文章信息/Info

Title:
 Expression of inducible nitric oxide synthase mRNA in various gastric changes tissue
作者:
 李晓丽1)△林锐2)李建生2)李继昌2)
 1)郑州大学第一附属医院老年病科;河南省高等学校临床医学重点学科开放实验室 郑州 450052
2) 郑州大学第一附属医院消化内科 郑州 450052
Author(s):
LI Xiaoli1) LIN Rui2)LI Jiansheng2)LI Jichang2)
1)Department of Geriatrics, the First Affilicated Hospital,Zhengzhou University;Open Laboratory of Key Science of Clinical Medicine of Henan Province, Zhengzhou 450052
2)Department of Gastroenterology,the First Affilicated Hospital, Zhengzhou University,Zhengzhou 450052
关键词:
胃癌诱导型一氧化氮合酶原位分子杂交法
分类号:
R735.2
文献标志码:
A
摘要:
目的:检测胃癌、癌前病变及慢性炎症胃黏膜组织中诱导型一氧化氮合酶(iNOS)mRNA的表达情况,探讨iNOS与胃癌发生发展的关系。方法:采用原位分子杂交法对35例慢性浅表性胃炎、24例慢性萎缩性胃炎伴肠化生、21例不典型增生及65例胃癌组织中iNOS mRNA表达进行检测。结果:iNOS mRNA在胃癌组织细胞中的表达明显增强,其阳性率(75.4%,49/65)与慢性浅表性胃炎(17.1%,6/35)、慢性萎缩性胃炎伴肠化生(45.8%,11/24)及不典型增生(52.4%,11/21)胃黏膜组织相比较,差异有统计学意义(χ2=31.646,P<0.001)。胃癌组织中iNOS mRNA的阳性表达与组织学分型、浸润深度及有无淋巴结转移有关(χ2分别为5.122、 5.182和13.213,P均<0.05),与肿瘤大小和肿瘤部位无关(χ2分别为1.866和0.366,P均>0.05)。结论:iNOS可能参与了胃癌形成的全过程,不仅与胃癌形成有关,且与胃癌的侵袭及转移有关。

参考文献/References:

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备注/Memo

备注/Memo:
 △女,1977年2月生,硕士,主治医师,研究方向:消化道肿瘤,E-mail:lxl039921@sina.com
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