[1]张红)△,李真珍),王志永),等.食管鳞状细胞癌组织中HIF1α和AQP1蛋白的表达*[J].郑州大学学报(医学版),2011,(03):335.
 ZHANG Hong),LI Zhenzhen),WANG Zhiyong),et al.Expression of hypoxiainducible factor1α and aquaporin 1 in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(03):335.
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食管鳞状细胞癌组织中HIF1α和AQP1蛋白的表达*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年03期
页码:
335
栏目:
食管癌研究
出版日期:
2011-05-15

文章信息/Info

Title:
Expression of hypoxiainducible factor1α and aquaporin 1 in esophageal squamous cell carcinoma tissue
作者:
张红12)△李真珍2)王志永23)赵阿红1)高冬玲1)
1)郑州大学第一附属医院病理科 郑州 450052   2)河南省高校临床医学重点学科开放实验室 郑州 450052   3)郑州市第一人民医院病理科 郑州 450052
Author(s):
ZHANG Hong12)LI Zhenzhen2)WANG Zhiyong23)ZHAO Ahong1)GAO Dongling1)
1)Department of Pathology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052   2)Institute of Clinical Medicine for Henan Universities,Zhengzhou 450052   3)Department of Pathology,the First People’s Hospital,Zhengzhou 450052
关键词:
水通道蛋白1缺氧诱导因子1α食管肿瘤鳞状细胞癌
文献标志码:
A
摘要:
目的:检测食管鳞状细胞癌(ESCC)组织中缺氧诱导因子1α(HIF1α)和水通道蛋白1(AQP1)蛋白的表达。方法:应用免疫组化SP法检测62例ESCC及其相应正常食管黏膜组织中HIF1α和AQP1蛋白的表达。结果:ESCC组织中HIF1α蛋白阳性表达率为80.6%(50/62),高于正常食管黏膜组织中的19.4%(12/62)(χ2 =30.083,P<0.001),并与ESCC组织学分级、TNM分期和淋巴结转移有关(χ2 =9.939、6.681和5.787,P均<0.05);ESCC组织中AQP1蛋白阳性表达率为61.3%(38/62),高于正常食管黏膜组织中的38.7%(24/62)(χ2=4.900,P=0.029),与ESCC组织学分级、TNM分期和淋巴结转移有关(χ2=9.102、9.836和8.020,P均<0.05);ESCC组织中HIF1α与AQP1蛋白的表达有关联(rP=0.292,P=0.016)。结论:高表达的HIF1α和AQP1与ESCC的发生发展有关。

参考文献/References:

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备注/Memo

备注/Memo:
*河南省科技厅普通科技攻关基金资助项目092300410069;河南省卫生厅创新人才基金资助项目200703046
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