[1]管一春)△,杨雪峰),王兴玲),等. 多囊卵巢综合征患者子宫内膜组织中同源框基因A10蛋白的表达[J].郑州大学学报(医学版),2011,(03):422.
 GUAN Yichun,YANG Xuefeng,WANG Xingling,et al. Expression of homeobox gene A10 in endometria of polycystic ovary syndrome patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(03):422.
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 多囊卵巢综合征患者子宫内膜组织中同源框基因A10蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2011年03期
页码:
422
栏目:
论著
出版日期:
2011-05-15

文章信息/Info

Title:
 Expression of homeobox gene A10 in endometria of polycystic ovary syndrome patients
作者:
管一春1)△杨雪峰2)王兴玲1)孙丽君1)王雪梅1)娄华1)李巍巍1)
 1)郑州大学第三附属医院生殖中心 郑州 450052
2)郑州大学第三附属医院妇产科 郑州 450052
Author(s):
 GUAN Yichun1)YANG Xuefeng2)WANG Xingling1)SUN Lijun 1)WANG Xuemei 1)LOU Hua1)LI Weiwei1)
 1)Reproductive Center,the Third Affiliated Hospital,Zhengzhou University, Zhengzhou 450052
2)Department of Gynaecology and Obstetrics,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
多囊卵巢综合征子宫内膜同源框基因A10
分类号:
R711.6;R321.3
文献标志码:
A
摘要:
 目的:检测多囊卵巢综合征(PCOS)患者子宫内膜组织中同源框基因(HOX)A10的表达。方法:采集20例已婚PCOS患者和26例已婚正常育龄妇女子宫内膜组织标本,HE染色判定内膜分期,采用免疫组化SP法检测不同患者子宫内膜HOXA10的表达。结果:PCOS患者子宫内膜间质反应不良和PCOS分泌中期组的子宫内膜分泌反应欠佳的发生率均高于对照者,差异有统计学意义(P=0.022和0.004)。4组间子宫内膜组织HOXA10蛋白的表达比较,差异有统计学意义(F=4.732,P<0.001)。其在PCOS和对照分泌中期子宫内膜的表达水平均高于相应的增生期组(P<0.05);在PCOS增生期和分泌中期组子宫内膜的表达水平均低于相应的对照组(P<0.05)。结论:PCOS患者内膜HOXA10的低表达可能参与了其内膜容受性下降的发生、发展过程。

参考文献/References:

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备注/Memo

备注/Memo:
 △女,1977年5月生,硕士,主治医师,研究方向:生殖内分泌,E-mail:lisamayguan@126.com
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